A B-cell line producing a human monoclonal antibody (HuMAb) against a recombinant 40-kDa outer membrane protein (OMP) of Porphyromonas gingivalis was constructed by in vivo immunization of a severe combined immunodeficiency C.B.-17/Icr mouse, which had been injected with human peripheral blood lymphocytes, with recombinant 40-kDa OMP and subsequent Epstein-Barr virus immortalization of B cells ...

Using archival materials from the National Archive of Republic Belarus, State Vitebsk region, Polotsk Zonal Archive, and Daugavpils Latvia, as well published documents Russian archives works historians, this article examines process preserving memory fallen soldiers Red (Soviet) Army on territory Belarusian- Latvian-Russian border in post-war Soviet period. The main conclusion is correctness (i...

Bmi-1, a polycomb gene family member, plays an important role in cell cycle regulation, cell immortalization, and cell senescence. Recently, numerous studies have demonstrated that Bmi-1 is involved in the regulation of self-renewal and differentiation of stem cells. However, the molecular mechanism underlying this biological process remains largely unclear. In the present review, we summarized...

1 2 3 The Epstein-Barr Virus BamHI C Promoter Is Not Essential For B Cell 4 Immortalization In Vitro But Greatly Enhances B Cell Growth Transformation 5 6 7 Rosemary J. Tierney # , Jasdeep Nagra, Martin Rowe, Andrew I. Bell and Alan B. Rickinson 8 9 School of Cancer Sciences, College of Medical and Dental Sciences, University of 10 Birmingham, Birmingham, United Kingdom. 11 12 Running Title: Ro...

USP7 (also called HAUSP) is a de-ubiquitinating enzyme recently identified as a key regulator of the p53-mdm2 pathway, which stabilizes both p53 and mdm2. We have discovered that the Epstein-Barr nuclear antigen 1 protein of Epstein-Barr virus binds with high affinity to USP7 and disrupts the USP7-p53 interaction. The results have important implications for the role of Epstein-Barr nuclear anti...