نتایج جستجو برای: immunoregulatory activity
تعداد نتایج: 1137202 فیلتر نتایج به سال:
The embryo, being half an antigenically “foreign” organism, should elicit a maternal immune response. During evolution, however, the mechanisms ensuring successful development of pregnancy have been formed. In particular, among factors providing tolerance during are some proteins associated with pregnancy. pregnancy-specific β 1-glycoprotein (PSG, PSG1; SP1; PSβG1) is dominant fetoplacental pro...
Inflammation is a very complicated phenomenon and consist a part of the immune response which is divided to a natural phase followed by an adaptive one. Tissue injury is followed by a cascade of events leading to the inflammatory response which is divided in three phases. The first phase of inflammation is manifested by the activation of the local tissue macrophagues which exert their phagocyti...
To understand further the biologic significance of the autologous mixed lymphocyte reaction, we determined the functional properties of autoreactive T cell lines and clones. Initially, we found that cells in an uncloned autoreactive Leu-3+ T cell line helped immunoglobulin production when added to cultures containing fresh T and non-T cells in the absence of pokeweed mitogen (PWM) but suppresse...
Although human amniotic fluid does contain different populations of foetal-derived stem cells, scanty information is available on the stemness and the potential immunomodulatory activity of in vitro expanded, amniotic fluid stem cells. By means of a methodology unrequiring immune selection, we isolated and characterized different stem cell types from second-trimester human amniotic fluid sample...
Bortezomib (BTZ) is a first-in-class proteasome inhibitor approved for the therapy of multiple myeloma that also displays unique regulatory activities on immune cells. The enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is a tryptophan metabolizing enzyme exerting potent immunoregulatory effects when expressed in dendritic cells (DCs), the most potent antigen-presenting cells capable of promoting e...
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