In this study, we compare the expression patterns of p53 mRNA and protein in normal human mammary epithelial cells following synchronization to different points in the cell cycle using two independent methods. When treated with lovastatin, the cells were blocked in G1 and appeared to express increased levels of wild-type p53 when examined by immunostaining. Upon reversal of the metabolic block,...

Abnormal function of the epidermal growth factor receptor (EGFR) has been recently shown to underlie various disorders cornification. Here we aimed at delineating genetic basis a novel dominant form palmoplantar keratoderma (PPK). Whole exome sequencing revealed heterozygous variants in CTSZ encoding cathepsin Z 4 affected individuals belonging 3 unrelated families. Bioinformatics and protein m...

objective: the role of wnt signaling and its antagonist; secreted frizzled related protein type 4 (sfpr4) was reported in rodent ovarian follicular development. this study examines immunolocalization of sfrp4 in ovaries of polycystic ovary (pco) rat model and evaluates its role in follicular growth arrest and its premature differentiation. materials and mathods: pco was induced with daily admin...

involvement of genetic alterations in breast cancer, one of the most common types of female malignancie, has been well documented . among the possible alterations, mutations in several genes including p53 as an important prognostic factor, have been extensively studied. mutated p5 protein has longer half-life than the wild type protein that is detectable by immunohistochemistry (ihc). our study...