Background: Splenic infarction (SI) is a rare clinical entity seldom encountered in veterinary medicine. Its most frequent causes include thromboembolic status, splenomegaly, and cardiac disease. Although thrombotic elements from the circulation provide the most common context for thromboembolic SIs, immune-mediated hemolytic anemia (IMHA) has not been reported as an underlying...

Two case reports in this issue of the Journal describe remarkably similar clinical presentations. The patients (a 37 year old woman1 with systemic lupus erythematosus and a 49 year old man2 with glomerulonephritis and pulmonary haemorrhage) presented with lung involvement which improved after immunosuppressive therapy was instituted. The patients were maintaoned on lower doses of immunosuppress...

In recent years, many new immunosuppressive drugs have been discovered and developed for clinical use in transplantation. This review focuses on those drugs (leflunomide, mycophenolate mofetil, sirolimus, tacrolimus) that have been shown to have immunosuppressive activity in patients. Different anti-interleukin-2 receptor antibodies are also reviewed as an example of a resurgence of development...