Numerous sublingual immunotherapy studies have shown efficacy using a wide variety of dosing regimens. Despite a few grade III and one anaphylactic reaction due to a patient over-dose, there have been no fatal reactions resulting from sublingual immunotherapy treatment. Although safer than SCIT, SLIT is still immunotherapy. Special consideration should be given to what will ensure the highest l...

Liver transplantation is accepted as an effective therapy for hepatocellular carcinoma (HCC). However, recurrence is one of the most fatal complications. The aim of this study is to evaluate the efficacy of intratumoral immunotherapy using IL-12 gene therapy and dendritic cell injection for the purpose of effective treatment for HCC under conditions of immunosuppression. We found that the combi...

Coronavirus disease 2019 (COVID-19), a multisystemic disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with both venous and arterial thromboses. The hypercoagulable state of the poses challenge to patient’s management. We herein report case ischaemic stroke in COVID-19 patient who had treated three days Baricitinib, an immunotherapy that can po...

background : nonmyeloablative chemotherapy followed by adoptive immunotherapy is an attractive strategy for depleting regulatory t cells in the host. however, its efficacy is transient. here, we aim to investigate whether cyclic chemoim- munotherapy has therapeutic efficacy against cancer. methods :we examined the efficacy of cyclic chemoimmunotherapy with cyclophos- phamide and adoptively tran...

The 22nd annual Cancer Research Institute (CRI) International Immunotherapy Symposiumwasheld fromOctober 5–8, 2014, in New York City. Titled "Cancer Immunotherapy: Out of the Gate," the symposiumbeganwith a Cancer Immunotherapy Consortium satellite meeting focused on issues in immunotherapy drug development, followed by five speaker sessions and a poster session devoted to basic and clinical ca...

Case reports have described an association between oral food/aeroallergen immunotherapy with the development of eosinophilic oesophagitis (EoE). The underlying mechanism of this is poorly understood, as is the role that both food/aeroallergen sensitisation plays in the pathogenesis of EoE. Specific immunotherapy has a long-standing history of use in the management of moderate/severe seasonal al...

Specific immunotherapy (SIT) is an effective treatment modality for allergic diseases when properly implemented. Standard allergen extracts have been shown to be beneficial in the treatment of allergic rhinitis and asthma. It has been shown in many studies that immunotherapy is the only therapeutic approach that may alter the natural course of allergic diseases if administered in appropriate do...

Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.

In 1890, Coley observed that cancer patients who developed infections had smaller tumors. From this, he developed Coley’s toxin and treated tumors with injections of infectious materials. In 1960s,  Mahaley used monoclonal antibodies to treat central nervous system(CNS)  tumors, that research and clinical investigations in brain tumor immunotherapy became a serious undertaking. ...

The application of nanomaterial in cancer treatment is promising and intriguing. Anti-tumor immunotherapy has the potential to significantly improve the prognosis of cancer treatment, though the efficacy of immunotherapy generally needs further improvement. One way to improve the efficacy is using immune adjuvants, but the adjuvants for anticancer immunotherapy have to be more potent than for p...