Consider a finite population of N elements identified by a set of indices U = {1, 2, ..., N}. Associated with each unit i in the population there is a study variable yi and a vector xi of auxiliary variables. Let A denote the set of indices for the elements in a sample selected by a set of probability rules called the sampling mechanism. Let the population quantity of interest be θN = ∑N i=1 yi...

The multiple imputation was developed as a general method for inference with missing data. Instead replacing the missing observation with a single value, multiple imputation method replaces each missing value with multiple plausible values. PROC MI in SAS creates multiply imputed data sets for incomplete multivariate data. This study reviews multiple imputation as an analytic strategy for missi...

BACKGROUND Recent focus on studying rare variants makes imputation accuracy of rare variants an important issue. Many approaches have been proposed to increase imputation accuracy among rare variants, from reference panel selection to combinations of existing methods to multistage analyses. We aimed to bring the strengths of these new approaches together with our proposed two-stage imputation f...

Missing data are vital subject to perform a proper longitudinal analysis. Some just ignore and discard all missing data to have complete dataset. However, it can result in a very substantial loss of information. Therefore, it is important to comprehend imputation methods of handling missing data. This paper discusses four common imputation methods for longitudinal analysis. Then, using simulati...

This report provides a review of the multiple imputation methodology used by the Sponsor (Acorn Cardiovascular, Inc.) to handle missing data in the analysis of the primary endpoint of its pivotal clinical trial of the CorCap Cardiac Support Device (CorCap), as well as an evaluation of the impact of multiple imputation on the results of that analysis. This included a completely blinded imputatio...

Fractional hot deck imputation, considered in Fuller and Kim (2005), is extended to multivariate missing data. The joint distribution of the study items is nonparametrically estimated using a discrete approximation, where the discrete transformation also serves to define imputation cells. The procedure first estimates the probabilities for the cells and then imputes real observations for missin...

Imputation estimates based on imputed values obtained from neural network models used in an 'impute first-aggregate next' approach, have been computed from Norwegian population census and administrative register data. The imputation estimates were compared with simple unbiased estimates obtained by the traditional 'aggregate first estimate next' approach and found to be superior for estimating ...

Multiple imputation is a common approach for handling missing data. It allows users to make valid inferences using standard complete-data methods with simple combining rules. A variation is to partition the missing data into two portions and conduct the imputation in two stages. We review two-stage multiple imputation and existing inferential methods and derive an alternative reference F -distr...

Sir, In a recent publication in Brain, Jack Jr et al. (2010) reported on the value of hippocampal atrophy and amyloid-b measures in predicting conversion from mild cognitive impairment to Alzheimer’s disease. The authors used data from 218 subjects in the Alzheimer’s Disease Neuroimaging Initiative with mild cognitive impairment, who had a measure of amyloid-b either through CSF amyloid-b42 or ...

OBJECTIVES Many classification problems must deal with data that contains missing values. In such cases data imputation is critical. This paper evaluates the performance of several statistical and machine learning imputation methods, including our novel multiple imputation ensemble approach, using different datasets. MATERIALS AND METHODS Several state-of-the-art approaches are compared using...