Fusion genes are known to be key drivers of tumor growth in several types of cancer. Traditionally, detecting fusion genes has been a difficult task based on fluorescent in situ hybridization to detect chromosomal abnormalities. More recently, RNA sequencing has enabled an increased pace of fusion gene identification. However, RNA-Seq is inefficient for the identification of fusion genes due to...

Abstract Laser powder bed fusion is an additive manufacturing process that employs highly focused laser radiation for selective melting of a metal bed. This entails complex heat flow and thermal management results in characteristic, often textured microstructures, which lead to mechanical anisotropy. In this study, high-energy X-ray diffraction experiments were carried out illuminate the format...

Process monitoring allows for unique opportunities to capture information at intermediate layers during fabrication part qualification, but also improve process robustness by identifying issues before yield or quality is reduced. An industrial-grade laser profilometer has been integrated the first time in a commercial polymer sintering machine and used monitor powder bed potentially qualify par...

We describe an unusual case of acute promyelocytic leukemia with +der(17)t(15;17) as the additional cytogenetic abnormality and with t(15;17) defined by fluorescence in situ hybridization (FISH) using a PML/RARA dual color, dual fusion translocation probe. By performing a step-by-step, complementary approach to evaluate unusual chromosomal abnormalities, we detected RARA/PML fusion on a marker ...

Lytic olisthesis is an accepted cause of low back pain and may also be associated with leg pain. When conservative treatment fails, operative management with fusion and if necessary decompression is considered. Most reports regarding surgical management in the literature relate to children or adolescents. This paper reviews 75 adult cases treated by in situ pedicular fixation and posterolateral...

Controlled fusion events between natural membranes composed of phospholipids with synthetic unnatural membranes will yield valuable fundamental information on the mechanism of membrane fusion. Here, fusion between vastly different phospholipid liposomes and cyclodextrin amphiphile based vesicles (CDVs) controlled by a pair of coiled coil forming lipidated peptides was investigated. Fusion event...