BACKGROUND Allergic asthma is characterized by bronchial inflammation and simultaneous repair processes that results in increased airway obstruction. Recent studies indicate that platelets could play an important role in this process. OBJECTIVES The aim of the present study was to evaluate the platelet count, the percentage of reticulated platelets, plasma thrombopoietin and interleukin 6 (IL...

asthma is a chronic inflammatory disorder of the airways. the stress is a factor for asthma which indicates a disorder in the function of communicational mediators of nervous and  immunological systems  such  as  neurotransmitters.  a  study  indicated  that  blood serotonin concentration increases in asthmatic patients. other study indicates that one kind of the serotonin  receptors, named 5ht...

More than 3 billion people worldwide are infected with parasitic worms called helminthes or suffer allergic disorders such as asthma, allergic rhinitis, food allergies and eczema. A common feature of these infectious or inflammatory conditions is the called allergic or “type 2” immune response. Type 2 immune responses are induced by and confer protection against helminthes, but can also play pa...

Allergic asthma is characterized by airway inflammation with a Th2-type cytokine profile, hyper-IgE production, mucus hypersecretion, and hyperreactivity (AHR). It increasingly recognized that heterogeneous disease implicating complex immune mechanisms resulting in distinct endotypes observed patients. In this study, we showed non-obese diabetic (NOD) mice, which spontaneously develop autoimmun...

Obesity is a known risk factor for allergic asthma. It has been recognized as a key player in the pathogenesis of several inflammatory disorders via activation of macrophages, which is also vital to the development of allergic asthma. We investigated the mechanism of obesity-related asthma and whether treating obesity through exercise or diet ameliorates the severity of asthma in the obesity-re...

Asthma (chronic allergic airways disease, AAD) is characterized by airway inflammation (AI), remodeling (AWR) and hyperresponsiveness (AHR). Current treatments for AAD mainly focus on targeting AI its contribution AHR, with the use of corticosteroids. However, there are no therapies direct treatment AWR, which can contribute to obstruction, AHR corticosteroid resistance independently AI. The ac...

Approximately 10% of all Australians and 14–16% of Australian children have asthma. Practice points • In patients with persistent allergic rhinitis, investigate for asthma (history, chest examination, pre-and post-bronchodilator spirometry if indicated). • In patients with asthma, investigate for rhinitis (history and physical examination). • In patients with both allergic rhinitis and asthma, ...

Abstract Respiratory syncytial virus (RSV) is a leading cause of childhood hospitalizations and increases the relative risk for development wheezing asthma following acute bronchiolitis. Previously, we observed increased allergic predisposition early life RSV infection in response to cockroach allergen (CRA) with concurrent alteration gastrointestinal microbiome mouse models allergy. Importantl...

Severe respiratory syncytial virus (RSV) infection has been hypothesized to be a risk factor for the development of allergy and asthma, but epidemiologic studies in humans have been inconclusive. By use of a well-characterized murine model of RSV infection and allergic sensitization with ovalbumin, the effect of a preceding severe RSV infection on the development of the pulmonary allergic infla...

Corticosteroids constitute the most effective current anti-inflammatory therapy for acute and chronic forms of allergic diseases and asthma. Corticosteroids are highly effective in inhibiting the effector function of Th2 cells, eosinophils, and epithelial cells. However, treatment with corticosteroids may also limit beneficial T cell responses, including respiratory tolerance and the developmen...