نتایج جستجو برای: induced liver injury dili
تعداد نتایج: 1452682 فیلتر نتایج به سال:
Anticoagulants are a well known cause of drug-induced liver injury (DILI). We recently encountered a 45-year-old male who developed DILI during treatment with enoxaparin, a low-molecular-weight heparin (LMWH), for dural venous thrombosis. The man received enoxaparin 80 mg subcutaneously, twice daily. After 4 days, the patient was asymptomatic but he developed liver aminotransferase elevations: ...
Herbal supplement-induced liver injury represents a growing concern in the body of drug-induced (DILI) literature, with recent studies mainland China, Iceland, and United States reporting estimated rates herb/dietary (HILI) between 1.16-6.38 per 100,000 (Björnsson et al., 2013; Shen 2019; Vega 2017). Notably, 2020 study demonstrated an increasing prevalence hepatotoxicity secondary to herbal di...
Drug induced liver injury (DILI) is an idiosyncratic adverse drug reaction leading to severe liver damage. Kupffer cells (KC) sense hepatic tissue stress/damage and therefore could be a tool for the estimation of consequent effects associated with DILI. Aim of the present study was to establish a human in vitro liver model for the investigation of immune-mediated signaling in the pathogenesis o...
The incidence of inflammatory bowel diseases (IBD) is rising worldwide. The therapeutic options for IBD are expanding, and the number of drugs with new targets will rapidly increase in coming years. A rapid step-up approach with close monitoring of intestinal inflammation is extensively used. The fear of side effects represents one the most limiting factor of their use. Despite a widespread use...
The utility of HepaRG cells as an in vitro cell-based assay system for assessing drug-induced liver injury (DILI) risk was investigated. Seventeen DILI-positive and 15 DILI-negative drugs were selected for the assay. HepaRG cells were treated with each drug for 24h at concentrations that were 1.6-, 6.3-, 25-, and 100-fold the therapeutic maximum plasma concentration (Cmax). After treatment, the...
Drug-induced liver injury (DILI), although rare, is a frequent cause of adverse drug reactions resulting in warnings and withdrawals of numerous medications. Despite the research community's best efforts, current testing strategies aimed at identifying hepatotoxic drugs prior to human trials are not sufficiently powered to predict the complex mechanisms leading to DILI. In our previous studies,...
Introduction Rapid advancement in high-throughput technologies, such as high-content assay/high-throughput screening methodologies, enables the assessment of cellular responses to hundreds of drugs in a single experiment. In addition, new approaches utilizing in vitro models (e.g., 3D cell culture), ‘omics’, organ-on-a-chip, and pluripotent stem cells (iPSC) have been introduced to evaluate dru...
BACKGROUND & AIMS We performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported genetic risk factors. METHODS We performed a GWAS of 862 persons with DILI and 10,588 population-matched controls. The first set of cases was recruited before May 2009 in Europe (n = 137) and the United Stat...
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