Crohn disease (CD) and UI-cerative Colitis (UC) are characterized by ulcerative lesions of the bowel. Some patients show similar lesions of the skin or oral and/or perianal mucosa. Sometimes these lesions, or some other skin lesions are the first sign of bowel disease. Dermatologists could suspect an inflammatory bowel disease (IBD) during skin lesions such as pyoderma gangrenosum (PG) or eryth...

Inflammatory bowel disease includes ulcerative colitis and Crohn's disease, which are both inflammatory disorders of the gastrointestinal tract. Both types of inflammatory bowel disease have a complex etiology, resulting from a genetically determined susceptibility interacting with environmental factors, including the diet and gut microbiota. Genome Wide Association Studies have implicated more...

Inflammatory Bowel Diseases--ulcerative colitis and Crohn's disease--are chronic gastrointestinal inflammatory diseases of unknown etiology. Decreased oral intake, malabsorption, accelerated nutrient losses, increased requirements, and drug-nutrient interactions cause nutritional and functional deficiencies that require proper correction by nutritional therapy. The goals of the different forms ...

including Crohn’s disease (CD) and ulcerative colitis (UC), have been recognized for many years now to include a hereditary component. Familial occurrence in IBD is probably expected to be less frequent in Greece compared to Northern Europe and America [3]. According to retrospective studies, fi rst-degree familial clustering of IBD in the Mediterranean area, including Greece, seems to not exce...

INFLAMMATORY BOWEL DISEASES AND AIR POLLUTION (Abstract). Air pollution is responsible for the increase in mortality, morbidity and a high number of hospitalizations for respir atory and cardio-vascular diseases. Recently, several studies have shown that air pollution can also affect the digestive system. The major impact was observed on inflammatory bowel diseases (Crohn’s disease and ulcerati...

The understanding of the intestinal inflammation occurring in the inflammatory bowel diseases (IBD) has been immeasurably advanced by the development of the now numerous murine models of intestinal inflammation. The usefulness of this research tool in IBD studies has been enabled by our improved knowledge of mucosal immunity and thus our improved ability to interpret the complex responses of mi...

The Westin Diplomat, Hollywood, FL, USA 13–15 December 2012 The Crohn’s and Colitis Foundation of America’s (CCFA) Conference, Advances in Inflammatory Bowel Diseases 2012, held in Hollywood (FL, USA), was co-chaired by Richard P MacDermott, from Albany Medical College (NY, USA) and Stephen B Hanauer, from the University of Chicago Medicine (IL, USA). This year’s conference saw a record 1947 to...

Crohn's disease and ulcerative colitis are chronic disabling inflammatory bowel diseases (IBDs). Although the causes of IBD are unknown, defects in innate and adaptive immune pathways have been identified and biological therapies that target key molecules have been designed. Infliximab, a chimeric immunoglobulin (Ig)G1 monoclonal antibody to tumor necrosis factor, dramatically improved treatmen...

In this review, we speculate about future therapeutic approaches for inflammatory bowel diseases (IBDs), focusing on the need for better preclinical and clinical models and approaches beyond small molecules and systemically administered biologics. We offer ideas to change clinical trial programs and to use immunologic and genetic biomarkers to personalize medicine. We attempt to reconcile past ...

BACKGROUND Enteric nervous system abnormalities have been described in patients with inflammatory bowel diseases. However, the mechanisms responsible for these abnormalities remain to date largely unknown. AIMS We investigated the potential role of apoptotic phenomena in enteric neurons and enteroglial cells in patients with inflammatory bowel diseases. PATIENTS AND METHODS Full-thickness s...