background: th e second leading cause of cancer deaths in women is breast cancer. germline mutations in susceptibility breast cancer gene brca1 increase the lifetime risk of breast cancer. eighty-one large genomic rearrangements (lgrs) have been reported up to date in brca1 gene, and evaluation of these rearrangements helps with precise risk assessment in high-risk individuals. in this study, w...

background: the relationship between thyroid autoimmunity and breast cancer is a challenging subject. we aimed to investigate this association in women with breast cancer. methods: in this descriptive study, 41 women with newly diagnosed breast cancer before receiving any pharmacologic treatment and 38 healthy age-matched women were enrolled. anti tpo ab (anti-thyroid peroxidase antibodies), ft...

background : biomarkers accepted for clinical use in breast cancer have low sensitivity and specificity. thus, there is a need for new markers to assist in the diagnosis, prognosis and follow-up of breast cancer patients. this study aims to investigate the diagnostic, prognostic and follow-up role of serum bcl-2, bax and p53 proteins in breast cancer patients in comparison with those of serum c...

PURPOSE: Inflammatory breast cancer (IBC) is an aggressive disease characterized by the formation of tumor emboli, rapid local invasion, and lymphatic dissemination. Furthermore, IBC rapidly develops therapeutic resistance and evades immune surveillance and attack. For these reasons, the treatment of inflammatory breast cancer is extremely challenging and new therapeutic approaches are needed. ...

Metastases to the breast from tumors other than breast carcinomas are extremely rare and represent only 0.2-1.3% of all diagnosed malignant breast tumors. Furthermore, while the most common sites for advanced ovarian cancer metastases are the liver, lung, and pleura, metastasis to the breast from a primary ovarian cancer is uncommon and has only been reported in 0.03-0.6% of all breast cancers....

Inflammatory breast cancer is a highly aggressive form of that forms clusters tumor emboli in dermal lymphatics and readily metastasizes. These cancers express high levels E-cadherin, the major mediator adherens junctions, which enhances formation emboli. Previous studies suggest E-cadherin promotes when balance between apical basolateral cadherin complexes disrupted. Here, we used immunohistoc...

Cancer stem cells (CSCs), which make up only a small proportion of heterogeneous tumor cells, may possess greater ability to maintain tumorigenesis than do other tumor cell types. Breast cancer tissue is reported to contain cancer stem-like cells. In order to eradicate tumor cells, various approaches have been taken to identify the critical molecules and signaling pathways in breast CSCs. Recen...

PURPOSE: Inflammatory breast cancer (IBC) is an aggressive disease characterized by the formation of tumor emboli, rapid local invasion, and lymphatic dissemination. Furthermore, IBC rapidly develops therapeutic resistance and evades immune surveillance and attack. For these reasons, the treatment of inflammatory breast cancer is extremely challenging and new therapeutic approaches are needed. ...

Broccoli, super detoxifying agent, crude extract was evaluated for antibreast cancer property in-vitro and in-vivo aspects. The in-vitro anti-cancer effect was applied on MCF7, human breast cancer cell line, obtained from Sweden. Breast cancer in rats was induced chemically by 7, 12-dimethylbenz-(a)anthracene (DMBA) administration. Antioxidant activity, anti-inflammatory biomarkers, estrogen an...

breast cancer is the most important and prevalent cancer in women that can be managed if detected in the early stages. recently, there has been much focus on the use of epigenetic changes such as dna methylation in early detection of cancer. as recent research has put forth dok7 cpg island methylation as an epimarker, in the present study, using a quantification method, a cohort of iranian spor...