introduction: inflammatory myofibroblastic pseudotumors are initially described in the lung and various extrapulmonary sites such as the orbits, palatine tonsils, ears, gingiva, pterygomaxillary space, and periodontal tissues. these tumors rarely involve the larynx and predilection to the glottis occurs in an indolent manner.   case report this case describes a laryngeal myofibroblastic tumor i...

Inflammation is a protective response to injury or tissue damage and acts by eliminating harmful stimuli such as pathogens cell initiates the healing process. Azadirachta indica was known medicinal plant with various pharmacological activities. This review aims summarize scientific activity of A.indica an anti-inflammatory, analgesic, antipyretic experimental models either in vivo vitro taken f...

background: the present study was designed to evaluate the secondary microglial activation processes after spinal cord injury (sci). methods: a quantitative histological study was performed to determine ed-1 positive cells, glial cell density, and cavitation size in untreated sci rats at days 1, 2, and 4, and weeks 1, 2, 3, and 4. results: the results of glial cell quantification along the 4900...

Inhibition of cyclooxygenase-2 (COX-2) has been extensively studied as an approach to reduce proinflammatory markers in acute brain diseases, but the anti-neuroinflammatory role cyclooxygenase-1 (COX-1) inhibition rather neglected. We report that m-terphenylamine derivatives are selective COX-1 inhibitors, able block microglia inflammatory response and elicit a neuroprotective effect. These com...

The host inflammatory response to HIV invasion is a necessary component of the innate antiviral activity that vaccines and early interventions seek to exploit/enhance. However, the response is dependent on CD4+ T-helper cell 1 (Th1) recruitment and activation. It is this very recruitment of HIV-susceptible target cells that is associated with the initial viral proliferation. Hence, global enhan...

Outer membrane vesicles (OMVs), secreted from Gram-negative bacteria, are spherical nanometer-sized proteolipids enriched with outer membrane proteins. OMVs, also known as extracellular vesicles, have gained interests for use as nonliving complex vaccines and have been examined for immune-stimulating effects. However, the detailed mechanism on how OMVs elicit the vaccination effect has not been...

Introduction: Astrocytes are the most abundant glial cell type. In addition to their neurological roles, astrocytes also have immune functions. They have been involved in antigen presentation in the central nervous system (CNS). Activated astrocytes express adhesion molecules, chemokines and release several inflammatory mediators, pro-inflammatory cytokines, neurotrophic and neuroprotective fac...

The present review aims to elucidate the emerging role played by cannabinomimetic compounds in the control of mast cell activation. Mast cells are immune competent cells strategically localised at the sites directly interfacing with the external environment, which, in case of injury, regulate the immune response by the release of a plethora of both pre-formed and newly-synthesised mediators. Ho...

Immune checkpoint inhibitors The incidence of myocarditis in patients using ICI is low, around 1%. However, several series describe mortality between 30% and 40%. This the primary reason that every effort made for myocardial protection early identification signs inflammatory response onset, addition to understanding T cell macrophage stimulation cytokine production., onset lesion most frequentl...

objective: astrocytes are the most abundant glial cell type. they may promote or inhibit cns inflammation depending on which cytokines are secreted. astrocytes also have immune roles. il-19, il-20, and il-24 activate a heterodimer receptor composed of the il-20r1 α-chain and the il-20r2 β-chain. it has long been considered that signaling by these receptor complexes affects immunological reactio...