The prevalence of cardiovascular disease in patients with renal failure is extremely high and accounts for a large part of the morbidity and mortality. Inflammation participates importantly in host defense against infectious agents and injury, but also contributes to the pathophysiology of many diseases, including cardiovascular atherosclerosis, which is a main problem in patients with renal fa...

Evidence indicates that the testis possesses a reduced capacity to mount inflammatory and rejection responses, which undoubtedly contributes to the ongoing survival of the highly immunogenic germ cells. The contribution of local cytokine expression to this condition was investigated in adult male rats treated with lipopolysaccharide to induce inflammation. Cytokine mRNA and protein expression w...

Diets rich in fruits and vegetables (FV), which contain (poly)phenols, protect against age-related inflammation and chronic diseases. T-lymphocytes contribute to systemic cytokine production and are modulated by FV intake. Little is known about the relative potency of different (poly)phenols in modulating cytokine release by lymphocytes. We compared thirty-one (poly)phenols and six (poly)phenol...

angiocardiography is an x-ray examination of the blood vessels or chambers of the heart. cardiologists and staff members applying this procedure are exposed to high levels of scattered radiation. in our previous study the incidence of unstable chromosomal aberrations and cytokinesis-blocked micronuclei were found to be significantly higher in exposed individuals than the age and sex matched con...

leukemia is a hematological tumor in which the malignant myeloid or lymphoid subsets play a pivotal role. newly identified t helper cell 22 (th22) is a subset of cd4(+) t cells with distinguished gene expression, function and specific properties apart from other known cd4(+) t cell subsets.th22 cells are characterized by production of a distinct profile of effector cytokines, including interleu...

newly  identified  t  helper  cell  22  (th22)  is  a  subset  of  cd4+t  cells  with  specific properties apart from other known cd4+ t cell subsets with distinguished gene expression and function. th22 cells are characterized by production of a distinct profile of effector cytokines, including interleukin (il)-22, il-13, and tumor necrosis factor-α (tnf-α). the levels of th22 and related cyto...

Effector function of T cells in autoimmune diabetes has been widely studied with mixed populations of lymphoid T cells stimulated ex vivo, but this approach does not permit evaluation of the contribution by a single T cell clone in the inflammatory site during pathogenesis. We have investigated cytokine production both in vitro and in vivo in a panel of diabetogenic CD4 Th1 T cell clones derive...

The effect of soluble antigenic (bovine serum albumin, BSA) stimulation to induce steroidogenesis in murine lymphoid organs with concomitant changes in proinflammatory or inflammatory cytokine levels and its implication in the alteration of T-cell response was studied in the mice. Male Swiss albino mice (6-8 weeks old) with average body weight (20 +/- 4 g) were randomly assigned to 3 groups and...

In this perspective article, we suggest that bacterial quorum-sensing signal molecules (QSSMs) be systematically screened and evaluated for their ability to exert anti-inflammatory activity in the context of COVID-19-associated cytokine storms other hyper-inflammatory conditions. Rapid relevant vitro screening these compounds (natural or synthetic) can accomplished by a careful choice assay sys...