Inflammatory bowel disease may be associated with different intracranial disorders. An inflammatory sellar mass is very rare but includes a variety of noninfectious causes including lymphocytic hypophysitis, granulomatous inflammation and Wegener's granulomatosis. A 32-year-old man was diagnosed with an inflammatory sellar mass associated with an extensive colonic inflammatory process clinicall...

Mast cells are a heterogeneous population of granulocytic cells in the immune system. Mast cell granules contain numerous mediators, including neurotransmitters, cytokines, chemokines and lipid-derived factors. In addition to their well-known role in immune inflammation, the presence of mast cells in the meninges and perivascular space in the central nervous system points to their role in brain...

Vagus nerve stimulation (VNS) is a technology that provides electrical to the cervical vagus and can be applied in treatment of wide variety neuropsychiatric systemic diseases. VNS exerts its effect by stimulating vagal afferent efferent fibers, which project upward brainstem nuclei relayed circuits downward internal organs influence autonomic, neuroendocrine, neuroimmunology systems. The neuro...

The ability to block specific cytokine pathways has revealed pathophysiological differences among autoimmune diseases (e.g., the efficacy of TNF inhibitors in arthritides and inflammatory bowel disorders their inefficacy giant-cell arteritis multiple sclerosis), providing a framework for reclassification.

OBJECTIVES The present study aimed to assess the relationship between inflammatory disorders with cardiometabolic diseases and mortality within a community-based population. METHODS The UK Biobank data were used to conduct two investigations: a cross-sectional study to estimate cardiometabolic risk and a prospective cohort study to estimate mortality risk. Binary regression analyses were used...

aim : the present study evaluated the association between g241r and k469e polymorphisms of intercellular adhesion molecule 1 gene and inflammatory bowel disease in iranian population.   background : inflammatory bowel disease including ulcerative colitis and crohn’s disease, is a chronic idiopathic inflammatory disease of the gastrointestinal tract. there are two single base polymorphisms of in...

Autism and Tourette syndrome are complex enigmatic disorders. Both are childhood neurological syndromes affecting behavior, social interaction, movement, and language. Like many complex disorders, autism and Tourette syndrome are thought to have complex genetic and environmental etiologies. Similarly, autoimmune and inflammatory (AI) disorders have complex multigenic and environmental origins. ...

BACKGROUND The aim of this study was to determine the prevalence and characteristics of rheumatologic manifestations associated with MDS. METHODS Eighty patients with MDS were evaluated by history and physical examination for inflammatory rheumatologic disorders from Jan 2013 to May 2014. Patients who had any signs or symptoms of rheumatologic disorders underwent evaluation by laboratory test...

The current review examines the relationship between depression and the inflammatory immune response. Mood disorders are a significant cause of morbidity and the etiology of depression is still not clearly understood. Many studies have shown links between inflammatory cytokines and mood disorders, including elevated level of cytokines like tumour necrosis factor-alpha (TNF alpha), Interleukins ...