UNLABELLED Spontaneous pain is often discussed in the context of both chronic inflammatory and neuropathic pain conditions, and it has been suggested that spontaneous pain, rather than stimulus-evoked pain, may be the more significant clinical problem. The following issues are discussed here. First, it is suggested that the concept of spontaneous pain makes no sense when the pain is the result ...

background: thiamine (vitb1) is a vitamin with various important physiological functions and postulated therapeutic effects.  its use as an analgesic in neuropathic pain has been undergoing in clinical settings. however, there has been little experimental investigation on this effect. in this study, anti-nociceptive and anti-inflammatory effects of thiamine were investigated in mice. methods: t...

Severe chronic pain is one of the hallmarks and most debilitating manifestations of inflammatory arthritis. It represents a significant problem in the clinical management of patients with common chronic inflammatory joint conditions such as rheumatoid arthritis, psoriatic arthritis and spondyloarthropathies. The functional links between peripheral inflammatory signals and the establishment of t...

Chronic inflammatory pain may result from peripheral tissue injury or inflammation, increasing the release of protons, histamines, adenosine triphosphate, and several proinflammatory cytokines and chemokines. Transient receptor potential vanilloid 1 (TRPV1) is known to be involved in acute to subacute neuropathic and inflammatory pain; however, its exact mechanisms in chronic inflammatory pain ...

background & aim: eugenia caryophyllata well known as clove is a tree from myrtaceae family that several parts of this plant traditionally used in dental care as an analgesic. this study aimed to assess the chemical composition, anti-inflammatory and anti-nociceptive activities of the essential oil extracted from clove buds. experimental: the essential oil of clove buds (eoc) was extracted ...

background & aim:zea mays leaf used traditionally in ibibio ethno medicine in southern nigeria to treat malaria and other inflammatory diseases. these anti-inflammatory and analgesic properties were evaluated against experimentally induced inflammation and pains using standard models. experimental: the effects of ethanol leaf extract of zea mays (170 -510 mg/kg) on experimentally induced inflam...

abstract explaining the etiology of complex regional pain syndrome (crps) from the psychogenic model is exceedingly unsophisticated, because neurocognitive deficits, neuroanatomical abnormalities, and distortions in cognitive mapping are features of crps pathology. more importantly, many people who have developed crps have no history of mental illness. the psychogenic model offers comfort to ph...

Human acute and inflammatory pain requires the expression of voltage-gated sodium channel Nav1.7 but its significance for neuropathic pain is unknown. Here we show that Nav1.7 expression in different sets of mouse sensory and sympathetic neurons underlies distinct types of pain sensation. Ablating Nav1.7 gene (SCN9A) expression in all sensory neurons using Advillin-Cre abolishes mechanical pain...

It has been reported that oscillatory gamma activity participates in brief acute pain and tonic ongoing pain. It is of great interest to determine whether the gamma activity is involved in chronic pain since chronic pain is a more severe pathological condition characterized by pain persistency. To investigate the oscillatory gamma activity in chronic pain, in the present study, we recorded spon...

Longus colli tendinitis (LCT) is an acute inflammatory condition with symptoms typically consisting of acute neck pain and stiffness with or without dysphagia. Once more severe etiologies for these symptoms are ruled out, this self-limiting condition usually resolves spontaneously with nonsteroidal anti-inflammatory drugs and corticosteroids. We present a case of LCT that presented as acute nec...