نتایج جستجو برای: influenza a h7n9 virus
تعداد نتایج: 13592173 فیلتر نتایج به سال:
Host-adaptive strategies, such as the E627K substitution in the PB2 protein, are critical for replication of avian influenza A viruses in mammalian hosts. Here we show that mutation PB2-K526R is present in some human H7N9 influenza isolates, in nearly 80% of H5N1 human isolates from Indonesia and, in conjunction with E627K, in almost all seasonal H3N2 viruses since 1970. Polymerase complexes co...
6. Kristensson K. Avian influenza and the brain – comments on the occasion of resurrection of the Spanish flu virus. Brain Res Bull 2006;68:406-413. The new emerging infection due to H7N9 influenza virus in China is the latest new outbreak for global concern1. As a bird flu, this infection is considered a zoonosis and results in serious clinical illness. As an atypical influenza infection, the ...
Influenza A viruses are important human and animal pathogens. Seasonal influenza viruses cause infections every year, and occasionally zoonotic viruses emerge to cause pandemics with significantly higher morbidity and mortality rates. Three cases of laboratory confirmed human infection with avian influenza A (H7N9) virus were reported in 2013, and there have been several cases reported across S...
The pandemic threat posed by emerging zoonotic influenza A viruses necessitates development of antiviral agents effective against various antigenic subtypes. Human monoclonal antibody (hMAb) targeting the hemagglutinin (HA) stalk offers a promising approach to control influenza virus infections. Here, we investigated the ability of the hMAb 81.39a to inhibit in vitro replication of human and zo...
The emergence of the novel H7N9 influenza A virus (IAV) has caused global concerns about the ability of this virus to spread between humans. Analysis of the receptor-binding properties of this virus using a recombinant protein approach in combination with fetuin-binding, glycan array and human tissue-binding assays demonstrates increased binding of H7 to both α2-6 and α2-8 sialosides as well as...
Introduction Since the emergence of avian influenza A(H7N9) virus in 2013, extensive surveillances have been established to monitor the human infection and environmental contamination with avian influenza virus in southern China. At the end of 2015, human infection with influenza A(H5N6) virus was identified in Shenzhen for the first time through these surveillances. These surveillances include...
Human infections with a novel influenza A H7N9 subtype virus were reported in China recently. The virus caused severe disease with high mortality rates and it raised concerns over its pandemic potential. Here, we assessed in the mouse model protective efficacy of single immunisations with low vaccine doses of insect cell-derived H7 virus-like particles, consisting of hemagglutinin and matrix pr...
BACKGROUND The sudden increase in the number of human cases infected with avian influenza A(H7N9) virus after September 2016 raised global concern. OBJECTIVES To assess the changes in epidemiological characteristics of H7N9 cases since the massive closure of live poultry markets (LPMs) in the main urban areas in Zhejiang province. METHODS We used descriptive statistics to compare epidemiolo...
BACKGROUND Human infection with avian influenza A H7N9 has emerged in China since February, 2013. The immunologic changes in pregnant women infected with H7N9 are not known. OBJECTIVE To report the clinical data and kinetic changes of immunity in a pregnant woman infected with H7N9 virus in Zhenjiang, Jiangsu, China. METHODS The clinical data were collected and immunity status was monitored...
The fifth epidemic wave of avian influenza A(H7N9) virus in China during 2016-2017 demonstrated a geographic range expansion and caused more human cases than any previous wave. The factors that may explain the recent range expansion and surge in incidence remain unknown. We investigated the effect of anthropogenic, poultry, and wetland variables on all epidemic waves. Poultry predictor variable...
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