نتایج جستجو برای: ingenol mebutate

تعداد نتایج: 232  

2016
Daniele C. Cary Koh Fujinaga B. Matija Peterlin

While highly active anti-retroviral therapy has greatly improved the lives of HIV infected individuals, these treatments are unable to eradicate the virus. Current approaches to reactivate the virus have been limited by toxicity, lack of an orally available therapy, and limited responses in primary CD4+ T cells and in clinical trials. The PKC agonist ingenol, purified from Euphorbia plants, is ...

Journal: :Cell host & microbe 2016
Amy E Baxter Julia Niessl Rémi Fromentin Jonathan Richard Filippos Porichis Roxanne Charlebois Marta Massanella Nathalie Brassard Nirmin Alsahafi Gloria-Gabrielle Delgado Jean-Pierre Routy Bruce D Walker Andrés Finzi Nicolas Chomont Daniel E Kaufmann

HIV cure efforts are hampered by limited characterization of the cells supporting HIV replication in vivo and inadequate methods for quantifying the latent viral reservoir in patients receiving antiretroviral therapy. We combine fluorescent in situ RNA hybridization with detection of HIV protein and flow cytometry, enabling detection of 0.5-1 gag-pol mRNA(+)/Gag protein(+)-infected cells per mi...

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