A synthesis procedure for heteroatom-substituted tetra(3,4-pyrido)porphyrazines that absorb light near 800 nm was developed. Based on the observed relationships between the structure and photophysical parameters, a novel highly photodynamically active (IC50 = 0.26 μM) compound was synthesized and biologically characterized.

A prominent theory of cognitive development attributes the poor performance that children show in many cognitive tasks to a general lack of inhibitory control. We tested this theory by examining children's inhibitory capabilities in retrieval-induced forgetting (RIF), a memory task in which selective retrieval of previously studied material causes forgetting of related, nonretrieved material. S...

Macrophage migration inhibitory factor (MIF) was the original cytokine, described almost 50 years ago and has since been revealed to be an important player in pro-inflammatory diseases. Recent work using MIF mouse models has revealed new roles for MIF. In this review, we present an increasing body of evidence implicating the key pro-inflammatory cytokine MIF in specific biological activities re...

Researchers have proposed that two processes featuring distinct types of inhibition support inhibitory control: a response threshold adjustment process involving the global inhibition of motor output and a conflict resolution process involving competitive inhibition among co-active response alternatives. To target the development of these processes, we measured the reaching behavior of 5- to 10...

Sixty-eight 3-year-old children participated in an investigation of inhibitory control (IC). Child IC was measured using various tasks in order to determine the impact on child performance of manipulating task demands. Performance on a nonverbal IC task, but not performance on more difficult motivational or traditional IC tasks, was explained by medial frontal electroencephalographic activity a...

This study investigated age-related changes in the early processing of novel visual stimuli using ERPs. Well-matched old (n=30), middle-aged (n=30), and young (n=32) subjects were presented standard, target/rare, and perceptually novel visual stimuli under Attend and Ignore conditions. Our results suggest that the anterior P2 component indexes the motivational salience of a stimulus as determin...

Past research has demonstrated negative associations between exposure to stressors and quality of interpersonal relationships among children and adolescents. Nevertheless, underlying mechanisms of this association remain unclear. Chronic stress has been shown to disrupt prefrontal functioning in the brain, including inhibitory control abilities, and evidence is accumulating that inhibitory cont...

People often encounter reminders to memories that they would prefer not to think about. When this happens, they often try to exclude the unwanted memory from awareness, a process that relies upon inhibitory control. We propose that the ability to regulate awareness of unwanted memories through inhibition declines with advancing age. In two experiments, we examined younger and older adults' abil...

We explored how relational complexity and featural distraction, as varied in scene analogy problems, affect children's analogical reasoning performance. Results with 3- and 4-year-olds, 6- and 7-year-olds, 9- to 11-year-olds, and 13- and 14-year-olds indicate that when children can identify the critical structural relations in a scene analogy problem, development of their ability to reason anal...