this paper investigates learner-initiated responses to english language teachers’ referential questions and learner initiatives after teachers’ feedback moves in meaning-focused question-answer sequences to analyze how interactional practices of language teachers, their initiation and feedback moves, facilitate learner initiatives. classroom discourse research has largely neglected learner init...

BACKGROUND Limited information exists on adults ≥50 years receiving HIV care in sub-Saharan Africa. METHODOLOGY Using routinely-collected longitudinal patient-level data among 391,111 adults ≥15 years enrolling in HIV care from January 2005-December 2010 and 184,689 initiating ART, we compared characteristics and outcomes between older (≥50 years) and younger adults at 199 clinics in Kenya, M...

Interferon regulatory factor-8 (IRF-8)/interferon consensus sequence-binding protein (ICSBP) is a transcription factor that controls myeloid-cell development. Microarray gene expression analysis of Irf-8-/- myeloid progenitor cells expressing an IRF-8/estrogen receptor chimera (which differentiate into macrophages after addition of estradiol) was used to identify 69 genes altered by IRF-8 durin...

Background: During last decades, many otologists attempted to make a long standing dry ear, resulting in better hearing after cholesteatoma surgery. This study evaluated the prognosis of two common methods of cholesteatoma ear surgery considering ten years follow-up. Methods: This retrospective analysis was done using medical records of 108 adult patients with cholesteatoma. After ten years of ...

Dear Editor, I was greatly interested in the article "Surgery in cholesteatoma: Ten years Follow-up" by Dr. M. Ajalloueyan published in your journal in March 2006; Vol 31, No 1: 37-40.I think there are grave misconceptions and many doubts about this article. That article has some misleading data that should be clarified by the author. The descriptions of table 1, "Statistical characteristics of...

The main pathway for the induction of type I interferons (IFN) by viruses is through the recognition of viral RNA by cytosolic receptors and the subsequent activation of interferon regulatory factor 3 (IRF-3), which drives IFN-alpha/beta transcription. In addition to their role in inducing an antiviral state, type I IFN also play a role in modulating adaptive immune responses, in part via their...