Social progress and demographic changes favor increased life expectancy and the number of people in situations of dependency. As a consequence, the demand for support systems for personal autonomy is increasing. This article outlines the vision @ home project, whose goal is the development of vision-based services for monitoring and recognition of the activity carried out by individuals in the ...

Aleksandr Butlerov synthesized the chemical in 1859, but it was August Wilhelm von Hofmann who identified it as the product formed from passing methanol and air over a heated platinum spiral in 1867. This method is still the basis for the industrial production of formaldehyde today, in which methanol is oxidized using a metal catalyst. By the early 20th century, with the explosion of knowledge ...

Latent factor models are increasingly popular for modeling multi-relational knowledge graphs. By their vectorial nature, it is not only hard to interpret why this class of models works so well, but also to understand where they fail and how they might be improved. We conduct an experimental survey of state-of-the-art models, not towards a purely comparative end, but as a means to get insight ab...

Neural constructivists have proclaimed, on the basis of arguments which it is suggested in the following are unconvincing, a view of the nervous system which has little place for innate knowledge relating to speciic domains. In this paper an alternative position is developed, which by instantiating innate knowledge in a exible manner provides a more credible alternative. It invokes dynamical sy...

Synthetic oligodeoxynucleotides containing CpG motifs trigger an innate immune response that typically increases host resistance to infection. Yet CpG treatment reduces the resistance of normal mice to Candida albicans infection. This effect is mediated by CpG-induced interleukin-12, indicating that CpG-dependent cytokine production may have adverse consequences for the host.

Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used ...

Link discovery is a new challenge in data mining whose primary concerns are to identify strong links and discover hidden relationships among entities and organizations based on low-level, incomplete and noisy evidence data. To address this challenge, we are developing a hybrid link discovery system called KOJAK that combines state-of-theart knowledge representation and reasoning (KR&R) technolo...

This paper presents a new algorithm for unsupervised incremental learning based on a Bayesian framework. The algorithm, called IGMM (for Incremental Gaussian Mixture Model), creates and continually adjusts a Gaussian Mixture Model consistent to all sequentially presented data. IGMM is particularly useful for on-line incremental clustering of data streams, as encountered in the domain of mobile ...

conclusions to date, a large number of viruses are proved to trigger innate immunity via tlrs, suggesting that these receptors are likely to be important in the outcome of viral infection. this suggestion is supported by the observation that many viruses have evolved mechanisms not only to evade the innate immune system, but also to subvert it for the benefit of the virus. materials and methods...