Inhibitory interneurons (INs) critically control the excitability and plasticity of neuronal networks, but whether activity can direct INs into specific circuits during development is unknown. Here, we report that in the dorsal lateral geniculate nucleus (dLGN), which relays retinal input to the cortex, circuit activity is required for the migration, molecular differentiation, and functional in...

The long non-coding RNA (lncRNA) GAS5 can be a marker for early diagnosis and postoperative follow-up in the patients with prostate cancer, whereby lower levels of correlate tumorigenesis unfavourable clinical course. Expression affected by rs145204276 polymorphism, 5 base pairs insertion-deletion polymorphism shown as ?AGGCA/-?. aim this study was to analyse association between cancer suscepti...

ion: The input term has the form "\x :: Dom D. e[x]" (x could be a pair). Add (x,D) to the database while parsing e[x] recursively, obtaining the result "(e’[x],E)". Return the pair ("lambda D(\x. e’[x])","cf(D,E)"). Strictly speaking, this is not a valid inference since a lambda abstraction need not be continuous just because it maps elements of its domain D to elements of its codomain E (see ...

Inertial navigation system (INS)/Doppler velocity log (DVL) integration is the most common navigation solution for underwater vehicles. Due to the complex underwater environment, the velocity information provided by DVL always contains some errors. To improve navigation accuracy, zero velocity update (ZUPT) technology is considered, which is an effective algorithm for land vehicles to mitigate ...

Recently, methods based on Artificial Intelligence (AI) have been suggested to provide reliable positioning information for different land vehicle navigation applications integrating the Global Positioning System (GPS) with the Inertial Navigation System (INS). All existing AI-based methods are based on relating the INS error to the corresponding INS output at certain time instants and do not c...

lnositol 1,4,5-trisphosphate [Ins( 1,4,5)P3] is produced by the phosphodiesteratic cleavage of the membrane lipid phosphatidylinositol4,S-bisphosphate in many cell types upon stimulation. It is thought to elevate intracellular free calcium ion concentration by stimulating release from a non-mitochondrial storage site [ 11. The mechanism by which Ins( 1,4,5)P3 exerts its action is largely unknow...

We have synthesized two photolabile arylazido-analogues of Ins(1,4,5)P3 selectively substituted at the 1-phosphate group for determination of Ins(1,4,5)P3-binding proteins. These two photoaffinity derivatives, namely N-(4-azidobenzoyl)aminoethanol-1-phospho-D-myo-inositol 4,5-bisphosphate (AbaIP3) and N-(4-azidosalicyl)aminoethanol-1-phospho-D-myo-inositol 4,5-bisphosphate (AsaIP3), bind to hig...

PURPOSE Infantile nystagmus syndrome (INS) can be idiopathic or associated with ocular or systemic disease. The ocular oscillation of INS directly contributes to loss of visual acuity. In this study, visual acuity development in patients with INS was examined. METHODS Children with INS were classified as having idiopathic INS (n = 84) or INS with an associated sensory deficit: INS and albinis...

BACKGROUND Vitamin D activity is controlled by vitamin D receptors (VDRs), which are affected by different genetic polymorphisms, including TaqI and Apal restriction fragment length polymorphisms (RFLPs), which have been reported to be associated with several diseases. The aim of this study was to determine the frequency and the association of VDR gene polymorphisms with idiopathic nephrotic sy...

C. reinhardtii sheds its flagella in response to acidification. Previously, we showed correlations between pH shock, deflagellation, and inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] production, but 100% of cells deflagellated by 5 s, which was the earliest that Ins(1,4,5)P3 accumulation could be accurately measured by techniques available to us at that time (Quarmby, L. M., Y. G. Yueh, J. L. Che...