The aim of this study was to investigate the effects of simvastatin on insulin secretion in mouse MIN6 cells and the possible mechanism. MIN6 cells were, respectively, treated with 0  μ M, 2  μ M, 5  μ M, and 10  μ M simvastatin for 48 h. Radio immunoassay was performed to measure the effect of simvastatin on insulin secretion in MIN6 cells. Luciferase method was used to examine the content of ...

We point out that, due to the nonlinearity of the Einstein equations, a homogeneous approximation in cosmology leads to the appearance of an additional term in the Friedmann equation. This new term is associated with the spatial inhomogenities of the metric and can be expressed in terms of density fluctuations. Although it is not constant, it decays much slower (as t− 2 3 ) than the other terms...

To evaluate the effect of intravenous infusion of a soybean based lipid emulsion (Lipovenoes 10%) on some blood constituents in sheep, a replicated 2 × 2 Latin square design experiment was conducted in four clinically healthy ewes. Lipid emulsion (LE group) or normal saline (NS group) was infused intravenously at a rate of 0.025 mL kg-1 per min for 6 hr and the concentrations of bloo...

The concentration of potassium in plasma is maintained within the normal range in man by many different physiological factors. The kidney is obviously of prime importance, as demonstrated by the hyperkalaemia which develops in renal failure [ 11. Several circulating hormones are, however, also of importance in potassium homoeostasis. Insulin enhances the uptake of potassium in muscle, liver and...

Electron cryo-microscopy has revealed the three-dimensional structure of a potassium channel that has a central role in regulating the release of insulin from the pancreas.

background: ovarian cysts are among the diseases which cause reproductive failure and economic losses in dairy herds. high yelding dairy cattles are suseptable to reproductive failure caused by ovarian cysts, as a result of their exposure to stressful coditions during lactation. objectives: this study aimed to monitor metabolic profile tests in dairy cows with ovarian cysts in comparison with c...

ZIERLER, KENNETH L. Effect of irtwlin on membrane potential and ~otass;Um content of rat muscle. Am. J. Physid. I 97 (3) : 5 I 5523. I g5g.-Insulin increased resting membrane potential of excised rat muscle, extensor digitorum longus, by about 5 mv in less than I hour. In I hour insulin caused no increase in the ratio of intrato extracellular potassium, but in 2-3 hours intracellular K increase...

Hyperglycemia at the time of hospital admission predicts increased mortality in patients with acute coronary syndromes (ACS), including ST-segment elevation myocardial infarction (STEMI) (1–6), revascularization procedures such as thrombolysis or percutaneous coronary intervention (PCI) (7–10), and other critical illnesses (11–13). The relationship between blood glucose and mortality appears li...

The effect of receptor occupancy on insulin receptor endocytosis was examined in CHO cells expressing normal human insulin receptors (CHO/IR), autophosphorylation- and internalization-deficient receptors (CHO/IRA1018), and receptors which undergo autophosphorylation but lack a sequence required for internalization (CHO/IR delta 960). The rate of [125I]insulin internalization in CHO/IR cells at ...

Hypokalemia and glucose intolerance may result from diuretic therapy. Increases in plasma insulin and glucose levels have been observed in thiazide-treated hypertensive patients and have been attributed to a diminished insulin sensitivity induced by diuretic therapy. To investigate the effects of hypokalemia on glucose tolerance and insulin secretion, we studied 21 essential and nine diabetic h...