Corresponding author: Hyeong Kyu Park Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul 04401, Korea E-mail: [email protected] Cardiovascular disease (CVD) is the main cause of morbidity and mortality in subjects with diabetes mellitus (DM). Strict glycemic control has been shown to reduce the ri...

OBJECTIVE To compare the use of metformin with that of insulin for the treatment of gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) unresponsive to diet therapy. MATERIALS AND METHODS In this prospective observational study, maternal glycemic control and perinatal outcome in diabetic pregnancies were compared between 2 obstetric units, one using insulin therapy and the...

Type 2 diabetes mellitus (T2DM) is a progressive disease associated with significant morbidity and mortality. There is good evidence that intensive glycemic control reduces the development and progression of complications in patients with diabetes. In order to achieve glycemic targets, patients often require a combination of oral therapy and/or insulin in addition to lifestyle modification. Unf...

While many studies have shown that intensive glycemic control can prevent the microvascular complications of diabetes, the benefits of intensive glycemic control in preventing macrovascular complications, including heart attacks, strokes, and overall mortality, have been less clear. Intensive glycemic control almost always increases the frequency and severity of hypoglycemic episodes. What rema...

OBJECTIVE To evaluate whether treatment with insulin is advantageous compared with oral antidiabetes agents in newly diagnosed type 2 diabetes with severe hyperglycemia after short-term intensive insulin therapy. RESEARCH DESIGN AND METHODS Newly diagnosed type 2 diabetic patients with severe hyperglycemia were hospitalized and treated with intensive insulin injections for 10-14 days. The ora...

10.2217/14750708.4.1.97 © 20 Critical illnesses associate with alteration in metabolic status. Insulin resistance and enhanced blood glucose levels occur during stressful situations, such as acute illnesses. These disturbances associate with poor prognostic events. Intensive insulin therapy and maintaining normoglycemia reduce the morbidity and mortality rate in critically ill patients. We aim ...

Before 2001, hospital hyperglycemia was often neglected. This approach changed dramatically when tight glycemic control came to the forefront of hospital medicine after a single-center, randomized controlled trial (RCT) in Leuven, Belgium, of more than 1,500 patients in a surgical intensive care unit (ICU) reported a 42% reduction in mortality rate with use of intensive insulin therapy. Since t...

The clinical utility and risk of strict glycemic control during critical care have been under intense debate. This study aims to elucidate the relationship between glycemic status and patient outcome in an integrated database collected at a tertiary teaching hospital. Clinical data of 16,135 critically ill adult patients with blood glucose measurements were extracted. The lowest blood glucose l...