The biological activities of chemokine (C-C motif) ligand 2 (CCL2) are mediated via C-C receptor-2 (CCR2). Increased CCL2 level is associated with metastasis many cancers. In our study, we investigated the role CCL2/CCR2 axis in development spontaneous intestinal tumorigenesis using ApcMin/+ mouse model. Ablation CCR2 mice significantly increased overall survival and reduced tumor burden. Immun...

Tuberculosis (TB) is a chronic infectious disease mainly caused by Mycobacterium tuberculosis (M. tuberculosis). The structures of polysaccharides and glycolipids at M. cell wall vary among different strains, which affect the physiology pathogenesis mycobacteria activating or inhibiting innate acquired immunity. Among them, some components such as lipomannan (LM) lipoarabinomannan (LAM) activat...

A 15-year-old male admitted for Pott's puffy tumor developed recurrent episodes of fever, diffuse morbilliform rash, eosinophilia, and tubulointerstitial nephritis while on multiple antibiotics. Lymphocyte blast transformation (LBT), a method of detecting cellular immune response by measuring levels of interferon-γ (IFN-γ), was used to diagnose vancomycin hypersensitivity and guide antibiotic s...

To investigate the effects of carvacrol supplementation in rainbow trout induced by lipopolysaccharide (LPS), relative gene expressions levels of some pro-inflammatory cytokines and apoptosis markers in kidney and liver were measured. Fish with a mean weight of 44.71±1.33 g were studied using four different treatments with three replicates each. Inflammation and apoptosis were performed using L...

Background: Lymphadenitis is the most common complication of BCG vaccination in children. Interferon-gamma (IFN-γ) plays a key role in immune response to Mycobacterial infections. In this study, the relationship of serum levels of IFN-γ and its receptor (CD119) to development of Bacillus Calmette Guerin (BCG) axillary lymphadenopathy was investigated. <em...

Abstract Background Interferon-γ (IFN-γ) is a major driver of excessive immune response, leading to intestinal mucosal damage and contributing the pathogenesis Crohn’s diseases (CD). In contrast inflammatory cells system, IFN-γ-induced cellular responses has not been well documented in epithelium. The epithelium consists multiple cell types patient-derived organoid model may be appropriate eval...

Background: The risk of infectious, autoimmune and immunodeficiency diseases and cancers rise in opioid addicts due to changes in innate and acquired immune responses. Three types of opioid receptors (К،δ،μ) are expressed on the surface of lymphocytes and mononuclear phagocytes. The present study was designed to examine the effects of different concentrations of opium on the secretion of some c...

Abstract Background To explore the differences of multiple cytokines secretion based on QuantiFERON-TB Gold Plus(QFT-Plus)antigens stimulation, and to screen with potential differentiate tuberculosis infection status. Methods Twenty patients diagnosed microbiologically active tuberculosis(ATB)in Peking Union Medical College Hospitaland Beijing Chest Hospital from February April 2022 were enroll...

Background: To explore the correlation of serum levels interleukin-2 (IL-2) and interferon-γ (IFN-γ) with clinical prognosis patients nasopharyngeal carcinoma (NPC) analyze risk factors.&#x0D; Methods: The data 195 NPC admitted to our hospital from October 2020 2022 were selected for retrospective study. who obtained 0 point in good group (group g), while those 1-2 points poor p) based on Glasg...

introduction:to evaluate the role of allergic-type and infectious-type cytokines in children with chronic otitis media with effusion (ome) materials and methods:we investigated serum levels of interleukins (il)-4, il-5, and il-13, along with interferon-gamma (ifn-γ) and tumor necrosis factor-alpha (tnf-α), by enzyme-linked immunosorbent assay (elisa) in 35 children with ome and 28 healthy contr...