D-[6-3H3]6-Deoxy-5-ketoglucose (10) and D-[5,6-3H2]6-deoxyglucose (11) were incorporated into neomycins B and C using a growing culture of Streptomyces fradiae. D-[6-3H]6-Deoxy-5-ketoglucose was incorporated into neomycin, as efficiently as the well established precursor D-glucose, and was found to label exclusively the 2-deoxystreptamine ring of the antibiotic. The results strengthened the pre...

10-((4-Hydroxypiperidin-1-yl)methyl)chromeno[4,3,2-de]phthalazin-3(2H)-one (E7016), an inhibitor of poly(ADP-ribose) polymerase, is being developed for anticancer therapy. One of the major metabolites identified in preclinical animal studies was the product of an apparent oxidation and ring opening of the 4-hydroxypiperidine. In vitro, this oxidized metabolite could not be generated by incubati...

A systematic survey of the different synthetic methodologies available for the syntheses of isoquinoline and yohimbinoid alkaloids revealed that the general approaches to these compounds involved either an A/B C — D/—i E approach or a D/E — C/B/A approach% We have now devised a novel method for the syntheses of both the isoquinoline and indole alkaloids belonging to the tetra— hydroprotoberberi...

in this paper, we introduce a class of $j$-quasipolar rings. let $r$ be a ring with identity. an element $a$ of a ring $r$ is called {it weakly $j$-quasipolar} if there exists $p^2 = pin comm^2(a)$ such that $a + p$ or $a-p$ are contained in $j(r)$ and the ring $r$ is called {it weakly $j$-quasipolar} if every element of $r$ is weakly $j$-quasipolar. we give many characterizations and investiga...

Here, we propose an add-drop and a channel drop filter based on two-dimensional photonic crystal all circular ring resonators. These structures are made of a square lattice of silicon rods with the refractive index n1=3.464 surrounded by air (with refractive index n2=1). The broadest photonic band gap occurs at the filling ratio of r/a = 0.17. Two linear defect W1 waveguides couple to the ring....

A frame $L$ is called {it coz-dense} if $Sigma_{coz(alpha)}=emptyset$ implies $alpha=mathbf 0$. Let $mathcal RL$ be the ring of real-valued continuous functions on a coz-dense and completely regular frame $L$. We present a description of the socle of the ring $mathcal RL$ based on minimal ideals of $mathcal RL$ and zero sets in pointfree topology. We show that socle of $mathcal RL$ is an essent...

L-Histidine labeled with deuterium at the C-5' position of the imidazole ring, L-[5'-2H]histidine (His-5'-D), was used as a probe for investigating a stepwise reversible mechanism via a carbanion intermediate in the elimination of ammonia catalyzed by histidine ammonia-lyase (EC 4.3.1.3). The labeled L-histidine (His-5'-D) (2.45 mM) was incubated with histidine ammonia-lyase (200 units) from Ps...

The reaction of ground state carbon atoms, C~Pj), with dimethylacetylene, H3CCCCH3 , was studied at three collision energies between 21.2 and 36.9 kJmol employing the crossed molecular beam approach. Our experiments were combined with ab initio and RRKM calculations. It is found that the reaction is barrierless via a loose, early transition state located at the centrifugal barrier following ind...

Since the isolation of potent cytotoxic communesins A and B from a marine fungal strain of Penicillium sp. in 1993,1 eight members (A-H) of this structurally intriguing indole alkaloid family were consecutively disclosed over the past 5 years2 (Figure 1). Although the polycyclic framework and multiple stereocenters of communesins have attracted intensive synthetic efforts toward skeletal constr...

a method is described by which it is possible to determine the high barrier to ring inversion and hindered rotation by neat racemization of optically active compounds when the racemization is caused by ring inversion or hindered rotation. the method is based preparation of sufficiently pure enantiomers, mainly by chromatography on swollen microcrystalline triacetylcellulose (tac). by this techn...