Research has shown that the knowledge worker, decisive driver of economy, works increasingly longer hours. In fact, it would appear instead working to live, they live work. There appears be three reasons for this living-to-work development. First, worker ‘has to’ on account pressure become ever more efficient. Such translates into internalized coercion in case self-responsible worker. Secondly,...

Canonical growth factors act indirectly via receptor-mediated signal transduction pathways. Here, we report on an autonomous pathway in which a growth factor is internalized, has its localization regulated by phosphorylation, and ultimately uses intrinsic catalytic activity to effect epigenetic change. Angiogenin (ANG), a secreted vertebrate ribonuclease, is known to promote cell proliferation,...

BACKGROUND Internalization of HIV-related stigma may inhibit a person's ability to manage HIV disease through adherence to treatment regimens. Studies, mainly with white men, have suggested an association between internalized stigma and suboptimal adherence to antiretroviral therapy (ART). However, there is a scarcity of research with women of different racial/ethnic backgrounds and on mediatin...

BACKGROUND We report a patient-centered intervention study in 9 municipalities of rural Nicaragua aiming at a reduction of internalized social stigma in new AFB positive tuberculosis (TB) patients diagnosed between March 2004 and July 2005. METHODS Five out of 9 municipal teams were coached to tailor and introduce patient-centered package. New TB patients were assigned to the intervention gro...

The exposure to CCR5 (CC chemokine receptor 5) specific natural antibodies in vitro produces a Class B β-arrestin2-dependent CCR5 retention with the aid of ERK1, due to the formation of a CCR5 signalosome, which remains stable for at least 48 h. Considering that β-arrestins and MAPKs are receptive to environmental signals, their signal complexes could be one of the key junction for GPCRs intern...

A qualitative retrospective study was conducted on 40 adults who experienced parental alienation as a child. Individuals participated in one-hour, semi-structured interviews. Audiotapes were transcribed verbatim and submitted to a content analysis for primary themes and patterns. Findings pertaining to the process of alienation from the targeted parent were analyzed for this article. Results re...

The paper starts by drawing the historical lines for and giving an account of the main methods and results from an empirical investigation of cognitive disorders in schizophrenics and communication deviances in their parents. The focus of the report is on the significant correlations that were found between some aspects of parents' style of communication and offsprings' cognitive functioning. O...

Tetanus neurotoxin (TeNT) and botulinum neurotoxins (BoNTs; from A to G) are metalloproteases that act on nerve terminals to prevent exocytosis. They are extensively exploited for the study of cellular physiology. Moreover, BoNTs are also employed in clinical neurology for the treatment of several disorders characterized by hyperexcitability of peripheral nerve terminals. This review summarizes...

Mitochondrial genetic disorders are a major cause of mitochondrial diseases. It is therefore likely that mitochondrial gene therapy will be useful for the treatment of such diseases. Here, we report on the possibility of mitochondrial gene delivery in skeletal muscle using hydrodynamic limb vein (HLV) injection. The HLV injection procedure, a useful method for transgene expression in skeletal m...

Weight-related issues (including excess weight, disordered eating and body concerns) are often considered as comprising distinct domains of 'obesity' and 'eating disorders'. In this commentary we argue that the concept of weight bias is an important variable when considering wellbeing across the spectrum of weight-related issues. We make the following six points in support of this argument: i) ...