BACKGROUND The triple epidemic of silicosis, tuberculosis and HIV infection among migrant miners from South Africa and neighbouring countries who have worked in the South African mining industry is currently the target of regional and international control efforts. These initiatives are hampered by a lack of information on this population. METHODS This study analysed the major South African m...

While we may not be able to find a cure for Alzheimer’s disease (AD) in the near future, several drugs presently in trials have shown promise as possible modifiers of disease progression. However, we may not be able to demonstrate efficacy due to issues of recruitment, retention, site-to-site variability, and other methodological issues. It is thus incumbent on the scientific community to find ...

OBJECTIVE To report the number of participants needed to recruit per baby born to trial staff during AVERT, a large international trial on acute stroke, and to describe trial management consequences. DESIGN Retrospective observational analysis. SETTING 56 acute stroke hospitals in eight countries. PARTICIPANTS 1074 trial physiotherapists, nurses, and other clinicians. OUTCOME MEASURES N...

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In the past decade tackling ‘abusive recruitment’ has catapulted to top of international migration governance agendas, largely in slipstream anti-trafficking advocacy. this context, Global Compact on Safe, Orderly and Regular Migration (GCM) aims ‘facilitate fair ethical while ‘safeguarding conditions that ensure decent work’. However, recruiters’ responsibility for systemic discriminatory raci...

INTRODUCTION Some specific pregnancy disorders are known to be associated with increased incidence of long-term maternal ill health (eg, gestational diabetes with late onset type 2 diabetes; pre-eclampsia with arterial disease). To what degree these later health conditions are a consequence of the woman's constitution prior to pregnancy rather than pregnancy itself triggering changes in a woman...

PURPOSE MRI cell tracking can be used to monitor immune cells involved in the immunotherapy response, providing insight into the mechanism of action, temporal progression of tumor growth, and individual potency of therapies. To evaluate whether MRI could be used to track immune cell populations in response to immunotherapy, CD8+ cytotoxic T cells, CD4+ CD25+ FoxP3+ regulatory T cells, and myelo...

Introduction. Patient recruitment is one of the main quantitative and qualitative characteristics a clinical trial. As characteristic, patients is, first all, final figure necessary to answer researcher's question; as process subject influence. The in center determined by rate per month allows you gain statistical power protocol, if does not reach planned capacity, then capacity may be gained t...