Intestinal bacteria have been shown to be important in regulating host intermediary metabolism and contributing to obesity. However, relatively less is known about the effect of intestinal bacteria on the expression of hepatic drug-processing genes in the host. This study characterizes the expression of hepatic drug-processing genes in germ-free (GF) mice using RNA-Seq. Total RNA were isolated ...

Lactic acid bacteria are present in many foods such as yoghurt and are frequently used as probiotics to improve some biological functions of the host. Many researchers have evaluated the effects of yoghurt and lactic acid bacteria against diseases such as cancer and intestinal inflammation. The preventive effect of probiotics on intestinal carcinogenesis may be associated with changes in the in...

Abnormal expression of CEACAM6 is observed at the apical surface of the ileal epithelium in Crohn's disease (CD) patients, and CD ileal lesions are colonized by pathogenic adherent-invasive Escherichia coli (AIEC). We investigated the ability of AIEC reference strain LF82 to colonize the intestinal mucosa and to induce inflammation in CEABAC10 transgenic mice expressing human CEACAMs. AIEC LF82...

The life span of intestinal epithelial cells (IECs) is short (3-5 days), and its regulation is thought to be important for homeostasis of the intestinal epithelium. We have now investigated the role of commensal bacteria in regulation of IEC turnover in the small intestine. The proliferative activity of IECs in intestinal crypts as well as the migration of these cells along the crypt-villus axi...

BACKGROUND Recent epidemiological analyses have implicated acute Campylobacter enteritis as a factor that may incite or exacerbate inflammatory bowel disease (IBD) in susceptible individuals. We have demonstrated previously that C. jejuni disrupts the intestinal barrier function by rapidly inducing epithelial translocation of non-invasive commensal bacteria via a transcellular lipid raft-mediat...

Particular intestinal bacteria are capable of metabolizing the soya isoflavone daidzein to equol and/or O-desmethylangolensin (O-DMA), and the presence of these metabolites in urine after soya consumption are markers of particular intestinal bacteria profiles. Prevalences of equol producers and O-DMA producers are approximately 30-50 % and 80-90 %, respectively, and limited observations have su...

The intestinal microbiota, epithelium, and immune system provide resistance to enteric pathogens. Recent data suggest that resistance is not solely due to the sum of the components, but that cross-talk between these components is also involved in modulating this resistance. Inhibition of pathogens by the intestinal microbiota has been called bacterial antagonism, bacterial interference, barrier...

Abstract The aim of the study was to analyse intestinal microbiota honey bees ( Apis mellifera ) treated with amitraz. In present study, microbiological profile bee intestines showed minor changes in following application A comparison numbers bacteria and fungi revealed a positive downward trend number fungi. decreased bacteria, included E. coli especially Clostridium spp., which were not isola...

Aflatoxin B1 (AFB1) is a food contaminant with detrimental impact on human and animal health. Intervention approaches focus on preand post-harvest measures to reduce AFB1 levels in crops or on the individual level to modulate bioactivation and excretion of AFB1 or reduce its bioavailability. Probiotic bacteria have been identified as a potential means to reduce availability of AFB1 as well as o...

Arq Gastroenterol • 2017. v. 54 no 2 Abr/Jun • 83 Bacteria usually co-exists with humans for millennium, and can be found in our bodies in many places, most of them in the gastrointestinal tract. They constitute the human microbiome formed by a great variety and diversity of microorganisms. It is estimated that 70% of these microorganisms are concentrated in the intestine, particularly in the c...