Musculoskeletal deficits are among the most commonly reported extra-intestinal manifestations and complications of inflammatory bowel disease (IBD), especially in those with Crohn’s disease. The adverse effects IBD on bone muscle multifactorial, including direct underlying processes, nutritional deficits, therapeutic effects. These factors also indirectly impact by interfering regulatory pathwa...

Ultrasonography and Contrast enhanced CT done in a 12 year old female, which shows wedge shaped hypo echoic lesions extending from periphery to hilum with no evidence of vascularity within. On follow-up plain these lesion appear dense areas non-enhancement post contrasting. Patient presented complaints fever pain left hypochondria. Antibiotic course Ceftriaxone was given following patient sympt...

Lynch syndrome is an autosomal-dominant disorder caused by defective DNA mismatch repair (MMR) genes and is associated with increased risk of malignancies in multiple organs. Small-intestinal adenocarcinomas are common initial manifestations of Lynch syndrome. To define the incidence and characteristics of Lynch syndrome-related small-intestinal adenocarcinomas, meticulous familial and clinical...

1Surgical Clinic I, County Hospital Timisoara, University of Medicine and Pharmacy Timisoara SUMMARY: The ischemic intestinal syndrome represents the totality of clinical manifestations caused by total or partial, abruptly or slowly reduction of the intestinal circulation. The diagnosis made by laparoscopy was very useful in critical patients with suspicion of mesenteric intestinal infraction b...

Behçet's disease (BD) is a chronic relapsing disease involving multiple organ systems. BD is characterized clinically by oral and genital aphthae, cutaneous lesions, and ophthalmological, neurological, and/or gastrointestinal manifestations. It is widely recognized that the presence of intestinal lesions may be a poor prognostic factor in intestinal BD, increasing the risk of surgery and decrea...

B7-H1 (PD-L1) on immune cells plays an important role in T cell coinhibition by binding its receptor PD-1. Here, we show that both human and mouse intestinal epithelium express B7-H1 and that B7-H1-deficient mice are highly susceptible to dextran sodium sulfate (DSS)- or trinitrobenzenesulfonic acid (TNBS)-induced gut injury. B7-H1 deficiency during intestinal inflammation leads to high mortali...

chronic granulomatous disease represents a group of inherited disorders of phagocytic system wherein recurrent infections are seen at different sites especially in the respiratory system. to determine the clinical spectrum of respiratory manifestations in chronic granulomatous disease patients, in this retrospective study, we used data from iranian primary immunodeficiency registry. the diagnos...

Toxic epidermal necrolysis (TEN) is life-threatening cutaneous adverse drug reaction characterized by extensive keratinocyte death. Gastrointestinal (GI) involvement in TEN is rare, however it contributes to poor prognosis. Here, we report a case of TEN with extensive intestinal involvement. A 56-year-old female was treated by zonisamide for fibromyalgia. Ten days later, generalized erythema ap...

Kawasaki disease is generally known as a systemic vasculitis that often concerns doctors due to its serious cardiac complications; however, other visceral organs may get involved as well. Surgical manifestations of the intestinal tract in Kawasaki disease are rare. In this report, we describe the case of a 2.5-year-old boy with typical Kawasaki disease who presented with GI bleeding and surgica...