prolonged residence of drug formulation in the nasal cavity is important for the enhancing intranasal drug delivery. the objective of the present study was to develop a mucoadhesive in-situ gelling nasal insert which would enable the reduced nasal mucociliary clearance in order to improve the bioavailability of metoclopramide hydrochloride. metoclopramide hydrochloride is a potent antiemetic an...

The aim of this study is to develop a locally acting nasal delivery system of triamcinolone acetonide (TA) for the maintenance therapy of allergic rhinitis. The effect of encapsulating TA in different nanocarriers on its mucosal permeation and retention as well as in vivo nasal deposition has been studied. A comparative study was established between polymeric oil core nanocapsules (NCs), lipid ...

In this work, the aerodynamics and particle flow patterns in the human nose are simulated by Computational Fluid Dynamics (CFD). The simulations were carried out by use of Fluent, and the volume grid was generated by Tgrid. To be able to perform successful CFD-calculations of the nose, construction of a proper surface grid of the nasal cavity was mandatory. A high resolution CT-scan was the fir...

OBJECTIVE To assess whether delivery of fluticasone propionate using a novel bi-directional delivery device (Opt-FP) offers therapeutic benefits in patients with chronic rhinosinusitis (CRS). METHODS A prospective, single centre, randomized, double-blind, placebo (PBO)-controlled, parallel group study was conducted in adult subjects (n=20) with CRS without nasal polyps or only cobblestoned mu...

Long-term oxygen therapy requires a practical regulated oxygen delivery system which works in the home. Although face-masks are cheap and efficient, they are awkward and need removal for talking and eating. Few patients would comply with this for 15 h her day. Nasal prongs are reliable, cheap, safe and well tolerated but are wasteful of oxygen. This waste is important both practically and finan...

Present review highlights the potential of nasal mucosa as an administration route for targeting the central nervous system, the brain. Targeted drug delivery seeks to concentrate the medication in the tissues of interest while reducing the relative concentration of medication in the remaining tissues. Thus improving efficacy of the drug and reducing side effects. The nasal mucosa when compared...

BACKGROUND The objective of this work was to review the literature concerning the distribution of topical therapeutics to the sinuses versus nasal cavity regarding: surgical state, delivery device, head position, and nasal anatomy and to provide evidence-based recommendations. METHODS A systematic review was conducted using Medline, EMBASE, and Cochrane databases to perform a Medical Subject ...

Parenteral administration of proteins/peptides requires repeated injections because of their extremely short biological half-life. Daily multiple injections are highly risky and require close medical supervision. Therefore, the delivery of proteins and peptides by routes other than parenteral route h s gained much attention in recent years. As a drug delivery route, nasal cavity offers several ...

When maximal anchorage is required during orthodontic treatment, additional aids are often needed to support the anchoring teeth. While intra-oral aids may be limited in their anchorage potential, extra-oral anchoring aids are often rejected by the patients. Endosseous implants may therefore be a valuable alternative for stable intra-oral anchorage. However, the possibility of using conventiona...

The purpose of this study was to compare the transverse dimensions of skeletal, dental, and nasal structures of a group of patients with maxillary narrowness before and after rapid maxillary expansion (RME) with an untreated control group using postero-anterior (PA) cephalometric radiographs. The material consisted of PA cephalograms of 25 children with a posterior crossbite (mean age 13 years ...