Local injection of glucocorticosteroid (GCS) is an effective treatment of painful conditions in the temporomandibular joint (TMJ). GCS can be administered using anatomical landmarks for orientation or by the use of simultaneous radiographic imaging. In the image guided technique the corticosteroid is mixed with a contrast medium and the injection visualized using radiography. The aim of this pr...

Mesenchymal stem cell (MSC)-based therapies may aid in the repair of articular cartilage defects. The purpose of this study was to investigate the effects of intraarticular injection of allogeneic MSCs in an in vivo anterior cruciate ligament transection (ACLT) model of osteoarthritis in rabbits. Allogeneic bone marrow-derived MSCs were isolated and cultured under hypoxia (1% O2). After 8 weeks...

Transforming growth factor beta (TGF-beta) induces leukocyte recruitment and activation, events central to an inflammatory response. In this study, we demonstrate that antagonism of TGF-beta with a neutralizing antibody not only blocks inflammatory cell accumulation, but also tissue pathology in an experimental model of chronic erosive polyarthritis. Intraarticular injection of monoclonal antib...

Transforming growth factor 3 (TGF-3) induces leukocyte recruitment and activation, events central to an inflammatory response. In this study, we demonstrate that antagonism of TGF-3 with a neutralizing antibody not only blocks inflammatory cell accumulation, but also tissue pathology in an experimental model of chronic erosive polyarthritis. Intraarticular injection of monoclonal antibody 1Dll....

INTRODUCTION Intraarticular hyaluronan (HA) is used clinically for symptomatic relief in patients with knee osteoarthritis (OA); however, the mechanism of action is unclear. In this study, we examined the effects of a single injection of HA on joint tissue pathology, mechanical allodynia and gait changes (measured by stride times) in a murine model of OA. METHODS OA was induced in the right k...

Objetivo: el objetivo de este estudio es presentar los resultados la inyección intraarticular PRP en personas con artropatía hemofílica

BACKGROUND Researchers initially proposed the substitution of apoptotic chondrocytes in the superficial cartilage by injecting mesenchymal stem cells (MSCs) intraarticularly. This effect was termed as bio-resurfacing. Little evidence supporting the treatment of osteoarthritis (OA) by the delivery of a MSC suspension exists. The aim of this study was to investigate the effects of injecting allog...

M e t h o d s Design: Randomized placebo-controlled trial. Allocation: {Concealed}†.* Blinding: Blinded (clinicians, patients, {data collectors, outcome assessors, data analysts, data safety and monitoring committee, and manuscript writers}†).* Follow-up period: 2 months. Setting: Alberta, Canada. Patients: 52 patients > 40 years of age (mean age 62 y, 60% women) with symptomatic hip OA for > 6...

Abstract Background Degenerative cartilage changes can be seen, in cases of lateral patellar compression syndrome, involving the patellofemoral joint. Hyaluronic acid is a natural component synovial fluid and responsible for its elastic features function articular surfaces. The aim this study to show effect intra-articular injection acid, after arthroscopic release on functional outcome knee pa...