نتایج جستجو برای: intrahepatic cholestasis of pregnancy
تعداد نتایج: 21189888 فیلتر نتایج به سال:
BACKGROUND Obstetric cholestasis (OC) is a serious problem in pregnancy. It affects about 4500 women per year in the UK. Affected women develop itching and occasionally jaundice. More importantly, the condition is associated with premature delivery, fetal distress and is believed to be an important cause of stillbirth. However, even now, there is no clear evidence as to whether the most popular...
OBJECTIVE Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-specific liver disease, is characterized by pruritus, abnormal liver function and elevated serum bile acid levels. The main cause of ICP has not yet been identified. We aimed to provide a new perspective to the pathogenesis of by investigating the possible association of circulating interleukin-17 (IL-17) that is...
BACKGROUND AND AIMS The aim of this study was to investigate the genetic aetiology of intrahepatic cholestasis of pregnancy (ICP) and the impact of known cholestasis genes (BSEP, FIC1, and MDR3) on the development of this disease. PATIENTS AND METHODS Sixty nine Finnish ICP patients were prospectively interviewed for a family history of ICP, and clinical features were compared in patients wit...
Post-liver transplant intrahepatic cholestasis is consequent to the impairment of bile flow or formation. It may develop in the early (within 6 months) or in the late (more than 6 months) post-liver transplant period and different causes may be recognized according to the time elapsed from a liver transplant. The raise at various degrees of serum bilirubin, alkaline phosphatase, and gamma-gluta...
When I received the editors’ invitation to review my research career “with emphasis obviously on cholestasis of pregnancy,” I felt like a conductor backstage at the Met when a voice over the loudspeaker calls, “Maestro, to the pit, please.” The bad news was that I should restrict the length of my symphony far less than my illustrious predecessors. I was born in Santiago, Chile, and studied medi...
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