It is possible to reduce the resistance of guinea pigs to tuberculosis by x-ray exposures, so that when animal inoculation is required for a diagnosis a much quicker result may be had than by the use of normal animals. In renal tuberculosis when it is necessary to resort to the use of animals, it ordinarily requires from 5 to 7 weeks, while by the use of x-rayed guinea pigs the diagnosis can be...

The idea that smallpox could be eradicated was not necessarily the ultimate aim when inoculation was introduced in Europe in the 1720s. This potentiality was not clearly articulated as an aim until the end of the eighteenth century. This article argues that during most of the eighteenth century, the main aim of inoculation was to lead people as safely as possible through what was regarded as an...

We examined the utility of infecting chicken embryos as a means of evaluating the virulence of different Francisella sp. strains and mutants. Infection of 7-day-old chicken embryos with a low dose of F. novicida or F. tularensis subsp. holarctica live vaccine strain (LVS) resulted in sustained growth for 6 days. Different doses of these two organisms were used to inoculate chicken embryos to de...

background: hepatitis b virus is one of the most common causes of chronic liver diseases. vaccination is the best way of prophylaxis and is of utmost importance. this study was conducted to compare the prophylactic effect of intradermal and intramuscular injection of hepatitis b vaccine. methods: a blind randomized clinical trial was performed among subjects who presented to the infectious dise...

Systemic administration of beta(2)-adrenoceptor agonists (beta(2)-agonists) can improve skeletal muscle regeneration after injury. However, therapeutic application of beta(2)-agonists for muscle injury has been limited by detrimental cardiovascular side effects. Intramuscular administration may obviate some of these side effects. To test this hypothesis, the right extensor digitorum longus (EDL...

ON 3 JANUARY 1793, Watson Alcock successfully completed the examination for membership of the Company of Surgeons.1 Shortly afterwards he began his career as a surgeon in Stockton-on-Tees. It is not known if he entered an established practice but he was involved in the sale of a house with Dr. Thomas Kirton,2 who was a well-established surgeon and died soon after. Watson Alcock was born in 1770...

This review discusses our current understanding of the growth and development of intramuscular fat and proposes a simple growth model to explain the accumulation of intramuscular fat in cattle. Potential effects of nutritional manipulation are discussed in relation to the proposed growth curve for intramuscular fat. The scope for nutritional control during both the pasture (or backgrounding) an...