Benign lymphoepithelial lesion (Mikulicz disease) is generally regarded as an inflammatory disorder of unknown aetiology, characterized by epimyoepithelial islands, and unrelated to malignant lymphoma. Five cases have been collected which show evidence at the same site of both Mikulicz disease and a malignant lymphoma. The latter took the form of reticulum-cell sarcoma or Hodgkin's disease. The...

PURPOSE To report a case of CD5+ primary intraocular B-cell lymphoma arising during methotrexate (MTX) and tumor necrosis factor (TNF) inhibitor treatment in a young patient with rheumatoid arthritis and uveitis. CASE PRESENTATION A 39-year-old woman treated with MTX and a TNF inhibitor for rheumatoid arthritis and uveitis had steroid-resistant vitreous opacity. A vitreous sample was obtained...

INTRODUCTION Currently, the detection of pathogens or mutations associated with intraocular lymphomas heavily relies on prespecified, directed PCRs. With metagenomic deep sequencing (MDS), an unbiased high-throughput sequencing approach, all pathogens as well as all mutations present in the host's genome can be detected in the same small amount of ocular fluid. METHODS In this cross-sectional...

A 52-year-old man with a history of malignant lymphoma of the cecum presented with lancinating facial pain in the left. Magnetic resonance imaging (MRI) revealed a tumor in the Meckel's cave extending along the trigeminal nerve. The tumor was partially removed via left retrosigmoid lateral suboccipital craniotomy. Histological examination showed findings consistent with diffuse large B cell lym...

Zinc, copper, and iron were measured in the pleural fluid of 86 patients with benign conditions (including congestive heart failure, pulmonary embolus, collagen disease, pneumonitis, nonspecific pleuritis, and tuberculosis) and in 116 patients with malignant disease (including lymphoma, breast carcinoma, primary lung cancer, and metastatic lung cancer). Though a positive correlation was found b...

Primary gastric lymphoma (PGL) is the most common type of extranodal that originates from lymphatic tissue within submucosa. In past two decades, treatment PGL has been overturned surgery to non-surgical individualized treatment, and its prognosis are different those other malignant lesions in stomach, so early diagnosis, accurate staging, timely monitoring outcome extremely important. Unlike i...

Purpose To report a rare case of secondary intraocular lymphoma treated with intravitreal rituximab, following pars plana vitrectomy. Observations A 74-year-old female with history of parotid gland large B-cell lymphoma presented bilateral intraocular recurrence 10 years after the onset of the primary malignancy. Systemic work-up including PET/CT Scan, bone marrow biopsy, brain MRI and CSF an...