background transurethral resection of the prostate (turp) is the most common surgical treatment for benign prostatic hyperplasia. objectives the aim of the present study was to compare the conventional bipolar transurethral resection of prostate (turp) with a modified transurethral resection of the prostate (m-turp) in men with mild to moderate symptoms of benign prostatic hyperplasia. patients...

Exercise training is an essential component of pulmonary rehabilitation and is associated with improved function and other important outcomes in persons with chronic lung disease. A subset of pulmonary rehabilitation patients experience hypoxemia that may occur or worsen with exercise. For the purpose of this review, severe exercise-induced hypoxemia is defined as an S(pO(2)) of < 89% during e...

Although exertional dyspnea and worsening hypoxia are hallmark clinical features of idiopathic pulmonary fibrosis (IPF), no drug currently available could treat them. GBT1118 is a novel orally bioavailable small molecule that binds to hemoglobin and produces a concentration-dependent left shift of the oxygen-hemoglobin dissociation curve with subsequent increase in hemoglobin-oxygen affinity an...

In sleep apnea syndrome (SAS), vigilance impairment is typically associated with highly disrupted sleep, but recently, nocturnal hypoxemia has also been identified as a second pathogenetic factor in patients with a high degree of desaturation. However, although sleep disruption has been demonstrated to play a role in both the propensity to fall asleep and the capacity to stay awake, the role of...

In newborns and adults of a number of species, exposure to acute hypoxemia produces a "regulated" decrease in core temperature, the mechanism of which is unknown. The present experiments were carried out in chronically instrumented newborn (5-10 days of age; n = 59) and older (25-30 days of age; n = 61) guinea pigs to test the hypothesis that the endogenous opioids mediate this regulated decrea...

The volume and complexity of thoracic procedures performed with a thoracoscopic approach are steadily increasing. Surgical exposure is paramount for thoracoscopic procedures and requires meticulous lung isolation. In this review, the physiological adaptive mechanisms that occur during one-lung ventilation (OLV) are discussed. Factors that predict the occurrence of hypoxemia during OLV and a str...