BACKGROUND AND OBJECTIVE Previous studies regarding the effects of some local anaesthetics have suggested that these agents can cause genetic damage. However, they have not been tested for genotoxicity related to repetitive administration. The aim of this study was to evaluate the genotoxic potential of local anaesthetics upon repetitive administration. METHODS 80 male Wistar rats were divide...

Objective: PDE5 inhibitors represent the first line therapy for treatment of ED. However, diabetic patients have poorer response compared with normal patients. The aim of this study was to determine whether taurine, a sulfurcontaining amino acid, affects diabetic erectile dysfunction. Methods: Type 1 diabetes mellitus was induced in male rats by streptozotocin (60 mg/kg, intraperitoneally). Aft...

The purpose of the present study was to elucidate the protective effects of ferulic acid (FA) against cyclophosphamide- (CTX-) induced changes in mice. Forty-eight male ICR mice were divided into four groups. Control group was intraperitoneally (i.p.) injected with 200 μL of phosphate buffer saline (PBS). Model group was intraperitoneally injected with a single dose of CTX (200 mg/kg). FA (50 m...

Objective: It was aimed to investigate the antigenotoxic effect of Ganoderma lucidum against damage caused by lipopolysaccharide (LPS) in rat bone marrow cells micronucleus test and comet analysis.
 Method: In experiment, 28 Wistar albino female rats were used 4 groups formed. Only physiological saline applied control group. A single dose 7.5 mg/kg LPS administered intraperitoneally LPS+ (...

Objective: To study the protective effect of Esculetin on myocardial injury induced by doxorubicin and explore mechanism in rats. Methods: Doxorubicin(2.5mg/kg) was injected intraperitoneally every other day for 6 times to establish a rat model injury. The effects different doses (10mg/kg & 20mg/kg) serum enzymes tissue were observed. Results: Doxorubicin significantly increased content int...

Background: Sclareol is a phytochemical used in people's diet in Southeast Asia. Objective: To investigate the immunotherapeutic effectiveness of Sclareol against breast cancer by direct intraperitoneal injection. Methods: Sclareol was isolated and purified from Salvia sclarea. Effect of Sclareol on cell growth inhibition was evaluated by MTT assay. Intraperitoneally injected Sclareol effects o...

INTRODUCTION Adhesions to mesh/tacks in laparoscopic ventral hernia repair are often cited as reasons not to adopt its evidence-based superiority over conventional open methods. This pilot study assessed the occurrence of adhesions to full-sized Polypropylene and Gore-tex DualMesh Plus meshes and the possibility for adhesion prevention using fibrin sealant. METHODS Two 10-cm to 15-cm pieces ...

An acute toxicity experiment was conducted to examine the distribution and depuration of microcystins (MCs) in crucian carp (Carassius aurutus) tissues. Fish were injected intraperitoneally with extracted MCs at a dose of 200 microg MC-LR (where L=leucine and R=arginine) equivalent/kg body weight. Microcystin concentrations in various tissues and aquaria water were analyzed at 1, 3, 12, 24, and...