Propofol is a widely used general anaesthetic with multisite mechanisms and especially ultrashort activation of certain central GABA-A receptors. Since its introduction into the market in the mid 1980s this is the seventh report on propofol dependence in the literature. The present case shows for the first time that craving for propofol can be quite intense and able to induce addictive behaviour.

were taken from this mixture at nine intervals for up to 128 min. Each sample was immediately acidified, stored at — 20 °C and subsequently transferred to Groningen for analysis. All samples revealed vecuronium without any of its breakdown products. Unlike the 3-hydroxy metabolite, neither of the two other metabolites of vecuronium (17-hydroxy and 3,17-dihydroxy vecuronium) have been detected p...

Modern policy analysis makes extensive use of dynamic stochastic general equilibrium (DSGE) models. These models differ significantly from earlier generations of large-scale econometric models. I review what I see as major progress in the ability of economists to conduct model-based policy analysis. This progress has come through the evolution in the types of models being used and in a refineme...

BACKGROUND It is still unknown whether anesthetic state transitions are continuous or binary. Mathematical graph theory is one method by which to assess whether brain networks change gradually or abruptly upon anesthetic induction and emergence. METHODS Twenty healthy males were anesthetized with an induction dose of propofol, with continuous measurement of 21-channel electroencephalogram at ...

The smoking habits of 202 patients presenting with sarcoidosis, as recorded in the clinical case records, were compared with figures from the General Household Surveys (GHS) to determine whether there was any association between smoking habit and sarcoidosis. In 19 there was no record of smoking habit. Of the remaining 183 patients, 40 (21.9%) were smokers, which was significantly less than exp...

PURPOSE OF REVIEW Adverse long-term impact of general anesthesia on the developing brain is a widely discussed and controversial issue with potential public health relevance. The goal of this article is to give insights into the most recent experimental and clinical observations aimed to advance our understanding in this field. RECENT FINDINGS Recent investigations demonstrate long-term behav...

Bromoform, first produced by Nunneley and Suchard about the year 1840, by the action of bromine on alcohol in the presence of an alkali, was, some twenty years later, tried by Rabuteau and others as a general anaesthetic, but does not appear to have been used much for this or for any medicinal purpose until, in 1889, S. K. Stepp,1 of Nuremberg, advocated it as a remedy for whooping cough. He re...

OBJECTIVE The aim of this study was to cross-culturally adapt the Armando Patient Satisfaction Questionnaire into Arabic and validate its use in the general population. METHODS The translation was conducted based on the principles of the most widely used model in questionnaire translation, namely Brisling's back-translation model. A written authorization allowing translation into Arabic was o...

BACKGROUND Patient awareness during general anaesthesia has considerable potential for severe emotional distress in the patient as well as professional, personal, and financial consequences for the anaesthetist. OBJECTIVES To examine the role of a previously described core algorithm "COVER ABCD-A SWIFT CHECK", supplemented by a specific sub-algorithm for awareness, in the detection and manage...

General anaesthesia was induced with, and maintained by, an infusion of either propofol or methohexitone, in patients undergoing surgery with the aid of regional blockade. Both agents provided satisfactory and controllable anaesthesia. Complications were few with a similar incidence for the two drugs. Recovery from anaesthesia was significantly faster following propofol.