BACKGROUND Iron deficiency is common in non-dialysis chronic kidney disease (ND-CKD) patients and, on occasion, requires parenteral iron therapy. We investigated the effect of intravenous iron repletion on platelet counts in ND-CKD patients with and without concomitant darbepoetin administration. METHODS We conducted a retrospective analysis of ND-CKD patients with iron deficiency anemia trea...

Hypoxia is a major cause of pulmonary hypertension. Gene expression activated by the transcription factor hypoxia-inducible factor (HIF) is central to this process. The oxygen-sensing iron-dependent dioxygenase enzymes that regulate HIF are highly sensitive to varying iron availability. It is unknown whether iron similarly influences the pulmonary vasculature. This human physiology study aimed ...

Background: Iron deficiency is a leading cause of anemia in pregnancy. The standard treatment majority the institutions oral iron, with blood transfusion reserved for severe or emergency cases. However, it unreliable anemia. aim this study was to compare efficacy and safety intravenous iron sucrose administration anaemia Methods: Hundred women gestational age between 30 34 weeks established hem...

OBJECTIVE (1) To determine an alternative iron supplementation with better efficacy, compliance & safety in treatment of iron deficiency anemia during pregnancy, (2) to reduce blood transfusion during pregnancy, labor and puerperium. MATERIAL AND METHOD A prospective comparative study. A total number of 60 pregnant women with the gestational age of 12-34 weeks were included in the study who w...

Erythropoietin stimulating agents had a long haul in Lithuania--we had no epoetin till 1994 and there was no intravenous iron in 2001-2004. The aim of this study was to assess the changes of renal anemia control in hemodialysis patients from early independence of Lithuania till nowadays and to evaluate the link of anemia with hospitalization rates and survival and hemoglobin variability in asso...

STUDY OBJECTIVE A safe alternative to erythropoiesis-stimulating agents to treat anemia is warranted in patients with cancer and anemia; thus the objective of this trial was to compare the efficacy and safety of intravenous (IV) iron isomaltoside with oral iron in patients with cancer and anemia by testing the noninferiority of IV versus oral iron. DESIGN Phase III, prospective, open-label, c...

OBJECTIVES This study was undertaken to assess the hematologic, clinical, and biochemical response to intravenous iron in patients with chronic heart failure (CHF) and anemia. BACKGROUND Anemia is common in patients with CHF and is associated with higher morbidity and mortality. The combination of erythropoietin (EPO) and iron increases hemoglobin (Hb) and improves symptoms and exercise capac...

Objectives: The objective of this study was to compare intravenous ferric carboxymaltose (FCM) versus iron sucrose in post-partum women with iron-deficiency anemia (IDA). Methods: This a hospital-based prospective randomized controlled study, comprising 100 post-natal IDA hemoglobin level <11 g/dL admitted ward the Obstetrics and Gynecology Department SP Medical College, Bikaner, from June 2...

To determine how best to assess iron status, I studied 12 young renal patients (ages 5.5 to 20 years) undergoing regular hemodialysis treatments. Iron balance was estimated by monitoring iron loss ascribable to blood loss during dialysis and diagnostic testing, and iron intake in the form of oral and intravenous iron supplements and blood transfusions. Traditional methods of evaluating iron sta...