In this paper register based family studies provide the motivation for linking a two-stage estimation procedure in copula models for multivariate failure time data with a composite likelihood approach. The asymptotic properties of the estimators in both parametric and semi-parametric models are derived, combining the approaches of Parner (2001) and Andersen (2003). The method is mainly studied ...

Telomere length (TL) is emerging as a biomarker for aging and survival. To evaluate factors influencing this trait, we measured TL in a large homogeneous population, estimated the heritability (h(2)), and tested for parental effects on TL variation. Our sample included 356 men and 551 women, aged 18-92 years, from large Amish families. Mean TL in leukocytes was measured by quantitative PCR (mea...

The area of our research is the phenomenon of social influence process and the role of person's and group's mentality in the conflict. Conflict implies the existence of at least two sides or parties, majority and minority (by its number, territory, resources and etc.). Until now the role of majority in social influence process was mainly studied considering the existing numerous psychological r...

The use of survival time models with non-proportional hazard functions is introduced as a method of studying age of onset effects in family studies. Statistical methods for investigating non-proportionality of the hazard function are described, and the application of these methods is illustrated using data from a family study of depression to investigate transmission of age of onset between pro...

The purpose of this paper was to review the theoretical underpinnings, major concepts, and methods of the typological approach. It was argued that the typological approach offers a systematic, empirically rigorous and reliable way to synthesize the nomothetic variable-centered approach with the idiographic case-centered approach. Recent advances in cluster analysis validation make it a promisin...

More than 20 different leukocyte or tissue antigens can presently be recognized; they belong to one complex system (HL-A) which is, from the genetic point of view, very similar to the H-2 system in the mouse. Another independent system consisting of two antigens has also been well defined, the Group Five system. The methods of defining these antigens, their tissue distri bution, and complex rel...

Genetic investigations with Zea mays have established ten linkage groups. Likewise, cytological investigations have revealed the presence of ten morphologically identifiable chromosomes composing the haploid complement (MCCLINTOCK 1929b). It is the aim of the present investigation to correlate a particular linkage group with a particular chromosome. The method employed has been to obtain 2nfl p...

India is one of the largest producers cotton in world, but productivity comparatively low. One major factors limiting pest infestation. Earlier production was inhibited by boll worms which now coped up with Bt sucking infestation still a prime concern. This study conducted F2 population four upland crosses- TVH002 x RAHC1039, TCH1894 NDLH32, CO17 KC2 and KC3, were evaluated for inheritance patt...