Iodine and its compounds have been used on an empirical basis in the treatment of various infectious diseases for many years. Its therapeutic efficacy in the past has been recorded in such diseases as the gumma of syphilis (1), North American blastomycosis, chromoblastomycosis and cryptococcosis (2). lodides are still recommended as specific therapy in sporo trichosis and their administration c...

A major disadvantage of (131)iodine (I)-labeled monoclonal antibodies (MAbs) for radioimmunotherapy has been the rapid diffusion of iodotyrosine from target cells after internalization and catabolism of the radioiodinated MAbs. We recently reported that a radioiodinated, diethylenetriaminepentaacetic acid-appended peptide, designated immunomedics' residualizing peptide 1 (IMP-R1), was a residua...

Radioiodine (I-131) therapy is of proven efficacy for treatment of differentiated thyroid carcinoma (DTC). However, loss of differentiation in recurrent or metastatic DTC which decrease I-131 uptake may decrease the efficacy of I-131 therapy. Therefore, strategies to improve I-131 uptake are mandatory. This study is an open label clinical study to evaluate the effectiveness of 13-cis retinoic a...

One of the major health consequences of the Chernobyl Nuclear Power Plant accident in 1986 was a dramatic increase in incidence of thyroid cancer among those who were aged less than 18 years at the time of the accident. This increase has been directly linked in several analytic epidemiological studies to iodine-131 (131I) thyroid doses received from the accident. However, there remains limited ...

The effect of anthropometric status on the efficacy of an oral supplement of iodised oil (1 ml Lipiodol Ultrafluide, 490 mg I; Laboratoire Guerbet, Aulnay-sous-Bois, France) was examined in 8-10-year-old schoolchildren (n 197) of Ntcheu, a severely I-deficient district of Malawi. The study was a controlled trial using the I concentration of casual urine samples to monitor the I status. The medi...

BACKGROUND Radioactive iodine 131 ((131)I) therapy has long been used in the treatment of differentiated thyroid cancers (DTC). While salivary and lacrimal glandular complications secondary to (131)I therapy are well documented, there is little in the literature addressing nasolacrimal duct obstruction (NLDO). We aimed to evaluate the frequency of (131)I therapy-acquired NLDO, its correlation t...

Abstract In this article, two proposed analytical model solutions of the steady-state advection-diffusion equation were carried out using technique advection diffusion multilayer method (ADMM), variable separation technique, Fourier transform, square complement method, general integrated transport (GITT) and Laplace transform. This work considers wind speed u, crosswind eddy diffusivity $${k}_{...

1. Ronga G, Fiorcntino A, Paserio E, et ai. Can iodinei 31 whole-body scan be replaced by thyroglobulin measurement in the post-surgical follow-up of differentiated thyroid carcinoma?./ Nud Med 1990:31:1766 -1771. 2. Joensuu H, Ahonen A. Imaging of metastases of thyroid carcinoma with fluorine-18-fluorodeoxyglucosc. J AW Med 1987;28:910-914. 3. Taher MA, Imaging metastases of thyroid carcinoma ...

This paper seeks to demonstrate to what extent alternative forms adopted in the working process of professionals with iodine-131 in nuclear medicine can assist in managing risks of ionizing radiation. The design is based on the main theoretical concepts of the psychodynamics of work in relation to workers' health. In the case study, data were gathered from 15 workers of a public health institut...

Therapy in nuclear medicine practice has a long distinguished history. Nuclear medicine therapy is required to be highly specific and targeted, since it always involves administration of unsealed sources of radioactivity. Most therapy agents utilize ß-particle emissions for their ability to penetrate tissues. This deposition of energy in tissue by ß emitters results in cellular damage. Among th...