Halogen bonds have been identified in a series of ionic compounds involving bromonium and iodonium cations and several different anions, some also containing hypervalent atoms. The hypervalent bromine and iodine atoms in the examined compounds are found to have positive σ-holes on the extensions of their covalent bonds, while the hypervalent atoms in the anions have negative σ-holes. The positi...

With the aim of developing a new SPECT imaging agent for the noradrenaline transporter, a twelve-step stereoselective synthesis of iodinated analogues of (2S,3R)- and (2R,3S)-reboxetine has been achieved from 4-bromobenzaldehyde. The key steps involve a Sharpless asymmetric epoxidation to establish the stereogenic centres and a copper catalysed aromatic halogen exchange reaction to introduce th...

A series of bis-chalcones (3a-g) and their flavones derivatives (4a-g) were synthesized and evaluated for their antimicrobial activity. Bis-chalcones were prepared by condensing 1,1'-(4,6-dihydroxy-1,3-phenylene)diethanone (2) with appropriate aryl aldehydes following Claisen-Schmidt reaction conditions. Oxidative cyclization of bis-chalcones (3a-g) in DMSO in the presence of iodine furnished f...

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BACKGROUND Currently, there are various antiseptics used for cleaning the skin before surgery, but there is no standard procedure in practice. Chlorhexidine and povidone-iodine are the most preferred compounds among antiseptics. Both are proved to be safe and effective for skin disinfection. In this study, our aim was to investigate the combined effects of chlorhexidine and povidone-iodine on t...

Positive stress or essential and nonessential elements can improve nutritive values (biofortification) of edible plants. In the present study, we evaluate (i) effect moderate salinity on lettuce biofortification, evaluated as nutritional bioactive compound accumulation, (ii) role iodine in enhancing salt tolerance by increasing photorespiration content antioxidants lettuce. Physiological (gas e...

Cyclic unsaturated ketone frameworks, which are obtained as the dearomatized products of phenols and their derivatives, valuable to synthesis complex molecules also contribute generation that can be readily employed for further transformations. Herein, use hypervalent iodine compounds access enantioenriched through direct stepwise dearomatization reactions have been elaborated. More information...

The recent report of poor iodine status in the UK is a wake-up call to health authorities in industrialized countries who have been slow to grasp that iodine deficiency (ID) is not confined to developing countries. Australia, New Zealand, Belgium, Norway and now the UK are all mildly iodine deficient. In the US, iodine intakes have fallen, and it is uncertain whether status is adequate in pregn...