Ionizing radiation has different biological effects according to dose and dose rate. In particular, the biological effect of low-dose radiation is unclear. Low-dose whole-body gamma irradiation activates immune responses in several ways. However, the effects and mechanism of low-dose radiation on allergic responses remain poorly understood. Previously, we reported that low-dose ionizing radiati...

Superoxide dismutases might conceivably protect against both ionizing radiation and free radical-producing antibiotic antitumor drugs. Copper- and zinc-containing superoxide dismutase (CuZn superoxide dismutase) and manganese-containing superoxide dismutase (Mn superoxide dismutase) were specifically assayed in human malignant tumors and for comparison in human tissues. The tumors possessed les...

Introduction: Nowadays ionizing radiation has a considerable contribution in medical diagnostic and treatment. Using ionizing radiation is increasing rapidly, so biological effects of ionizing radiation should be considered more. X-rays in the range of diagnostic radiology have hazardous effects and risks that are defined as random effects. These effects obey the LNT hypothesis that occur at lo...

elevated amount of the free radicals due to ionizing radiation causes deteriorating damage on immune system. therefore, we made attempts to investigate the protective effect of vitamin e (vit-e), a biological antioxidant in balb/c mice, so as to find an affordable prophylactic supplementation for individuals who are at risk. several groups of mice were selected and exposed to sub-lethal g -irra...

Leukemia/lymphoma-related factor (LRF) is a POZ/BTB and Krüppel (POK) transcriptional repressor characterized by context-dependent key roles in cell fate decision and tumorigenesis. Here we demonstrate an unexpected transcription-independent function for LRF in the classical non-homologous end joining (cNHEJ) pathway of double-strand break (DSB) repair. We find that LRF loss in cell lines and m...

Radiation is any kind of energy transmitted without an intermediate medium. Radiant generally wave-shaped, most commonly sinusoidal. There are two types radiation: ionizing radiation and non-ionizing radiation. Ionizing that causes the process ejecting electrons from atoms to form ion pairs. Attention should be paid radiation, particularly its sources, types, properties, effects, methods avoida...

Aging stem cells lose the capacity to properly respond to injury and regenerate their residing tissues. Here, we utilized the ability of Drosophila melanogaster germline stem cells (GSCs) to survive exposure to low doses of ionizing radiation (IR) as a model of adult stem cell injury and identified a regeneration defect in aging GSCs: while aging GSCs survive exposure to IR, they fail to reente...

The very word "radiation" conjures up scary images – nuclear weapons, cancer therapy, perhaps a science fiction movie scenario with giant mutant ants. In fact, radiation in one form or another is a part of our daily lives. Understanding what radiation, or specifically, ionizing radiation, is can help you understand what risks you face. Although ionizing radiation is a broad topic, we will exami...

Crohn's disease is a chronic disease with an unpredictable course. Patients with Crohn's disease will have to undergo numerous imaging tests. Crohn's disease often affects young people, who are more vulnerable to the harmful effects of repeated exposure to ionizing radiation. The high resolution of tissues on MR enterography give it a diagnostic accuracy similar to that of CT; however, MR enter...