نتایج جستجو برای: irak4
تعداد نتایج: 227 فیلتر نتایج به سال:
To identify genetic events that characterize cancer progression, we conducted a comprehensive genetic evaluation of 161 primary breast tumors. Similar to the "mountain-and-hill" view of mutations, gene amplification also shows high- and low-frequency alterations in breast cancers. The frequently amplified genes include the well-known oncogenes ERBB2, FGFR1, MYC, CCND1, and PIK3CA, whereas other...
Polymorphonuclear neutrophils (PMN) play a key role in innate immunity. Their activation and survival are tightly regulated by microbial products via pattern recognition receptors such as TLRs, which mediate recruitment of the IL-1R-associated kinase (IRAK) complex. We describe a new inherited IRAK-4 deficiency in a child with recurrent pyogenic bacterial infections. Analysis of the IRAK4 gene ...
BACKGROUND Bupleurum polysaccharides (BPs), isolated from Bupleurum smithii var. parvifolium, possesses immunomodulatory activity, particularly on inflammation. Bacterial endotoxin lipopolysaccharide (LPS) triggers innate immune responses through Toll-like receptor 4 (TLR4) on host cell membrane. The present study was performed to evaluate whether the therapeutic efficacy of BPs on suppression ...
Sweet Syndrome (SS) is a prototypic neutrophilic dermatosis. Experimental studies focusing on SS are limited due to the rarity of disease. We performed gene expression profiling skin biopsies from 12 patients and 5 healthy controls (HC) with similar sex ratio age ranges using NanoString nCounter technology. Unsupervised clustering based revealed clear separation between HC. Analysis differentia...
[This corrects the article on p. 83 in vol. 5, PMID: 28503543.].
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