Fully dispersible, cationic ultrasmall (7 nm diameter) superparamagnetic iron oxide nanoparticles, exhibiting high relaxivity (178 mM(-1)s(-1) in 0.47 T) and no acute or subchronic toxicity in Wistar rats, were studied and their suitability as contrast agents for magnetic resonance imaging and material for development of new diagnostic and treatment tools demonstrated. After intravenous injecti...

We present a potential theranostic delivery platform based on the amphiphilic diblock copolymer polybutadiene-block-poly (ethylene oxide) combining covalent fluorescent labeling and membrane incorporation of superparamagnetic iron oxide nanoparticles for multimodal imaging. A simple self-assembly and labeling approach to create the fluorescent and magnetic vesicles is described. Cell uptake of ...

Introduction MRI is a high spatial resolution non-invasive technique but it has low specificity for targeting explicit pathologies. In an effort to improve specificity, MRI contrast agents with strong paramagnetic properties such as Gadolinium have been developed. However recent reports of suspected deaths associated with gadolinium administration have severely limited their use [1-2]. Iron oxi...

Oils containing both fluorescent semiconductor and magnetic oxide nanoparticles are used to produce oil in water emulsions. This technique produces oil droplets with homogeneous fluorescence and high magnetic nanoparticle concentrations. The optical properties of the oil droplets are studied as a function of the droplet sizes for various concentrations of fluorescent and magnetic nanoparticles....

BACKGROUND To quantitatively compare in-vitro and in vivo membrane transport studies of targeted delivery, one needs characterization of the magnetically-induced mobility of superparamagnetic iron oxide nanoparticles (SPION). Flux densities, gradients, and nanoparticle properties were measured in order to quantify the magnetic force on the SPION in both an artificial cochlear round window membr...

In this study a liposome cell labeling system was developed for non-target-specific labeling of glioma cells with superparamagnetic iron oxide nanoparticles for magnetic resonance imaging (MRI). A high non-target-specific uptake is ideal for in vitro labeling of cells and subsequently for cell tracking and visualization of phagocytic cells in vivo. The preparation of iron oxide-loaded liposomes...

Diatom silica microcapsules prepared by purification of diatomaceous earth (DE) were functionalised by dopamine modified iron-oxide nanoparticles, in order to introduce diatoms with magnetic properties. The application of magnetised diatoms as magnetically guided drug delivery microcarriers has been demonstrated.

A novel strategy for delivering functionalised superparamagnetic iron oxide nanoparticles to the outer surface of pancreatic islet grafts, using chemically modified polymeric nanolayers, has been developed for tracking of engrafted pancreatic islets by magnetic resonance imaging.

Introduction Magnetic oxide nanomaterials, including iron oxide (Fe3O4 and γ-Fe2O3), spinel ferrites (MFe2O4; M=Mn, Zn, Cr, Ni, or Co) and hexagonal ferrite (MFe12O19, M=Ba and Sr) are attracting much attention due to their wide application potentials in advanced magnets, electronic devices, information storage, magnetic resonance imaging (MRI), and drug-delivery technology [1-6]. Hence, the sy...

BACKGROUND Superparamagnetic iron oxide nanoparticles have been used in clinical applications as a diagnostic contrasting agent. Previous studies showed that iron oxide nanoparticles deposited in the liver and spleen after systemic administration. The present study investigated the effect of iron oxide nanoparticles on antigen-specific immune responses in mice sensitized with the T cell-depende...