BACKGROUND Multiple randomized trials comparing mastectomy to lumpectomy and whole breast irradiation (WBI) have shown equivalent survival outcomes in early-stage breast cancer. WBI requires a treatment course of several weeks, which has resulted in limited access to breast-conserving therapy in certain populations. A shorter accelerated course of partial breast irradiation (APBI) has been inve...

objective: the out-of-field/non-target effect is one of the most important phenomena of ionizing radiation that leads to molecular and cellular damage to distant non-irradiated tissues. the most important concern about this phenomenon is carcinogenesis many years after radiation treatment. in vivo mechanisms and consequences of this phenomenon are not known completely. therefore, this study aim...

There is little information on the fate of infused mesenchymal stem cells (MSCs) and long-term side effects after irradiation exposure. We addressed these questions using human MSCs (hMSCs) intravenously infused to nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice submitted to total body irradiation (TBI) or local irradiation (abdominal or leg irradiation). The animals were sacr...

Irradiation and storage increased lipid oxidation of normal and pale-soft-exudative (PSE) muscles, whereas dark-firm-dry (DFD) muscle was very stable and resistant to oxidative changes. Irradiation increased redness regardless of pork-quality type, and the increases were proportional to irradiation dose. Irradiation increased the production of sulfur-containing volatiles, but not lipid oxidatio...

a simple, fast, efficient and environmentally friendly method for synthesis of benzimidazole and its 2-alkyl, aryl and heteroaryl substituted derivatives was developed using zeolite hy. two component cyclolcondensation of 1,2-phenylenediamine (o-phenylenediamine) and commercially available carboxylic acids catalyzed by zeolite hy without any solvent, under microwave irradiation led to formation...

the radioprotective effects of vitamin c and famotidine were investigated using the micronucleus test for anticlastogenic and cell proliferation activity. various doses of vitamin c and famotidine were administered intraperitoneally 2 h before 2gy gamma irradiation to nmri adult male mice. frequency of micronuclei in 1000 pces (mnpces) were scored for each sample. cell proliferation ratio (pce/...

gamma irradiation is routinely used for suppression of lymphocyte function in transfusion and transplantation procedures. in recent years, some investigators focused on the effects of ionizing radiation on special aspects of lymphocyte function and considered the possibility of its clinical application for treatment of some immunological disorders. in this study, we evaluated the effects of fiv...

background: haemonchus contortus causes severe economic losses in small ru-minants, so this study was conducted to study the uv effect on h. contortus larvae and its protective effect. methods: sixteen male goats were divided into 5 groups, control infected, con-trol uninfected and uv 30minutes exposure; uv 60minutes exposure and uv booster 60minutes exposure. the uv groups were exposed to uv i...

as benzimidazole ring is an important pharmacophore in modern drug discovery and benzimidazoles are very important intermediates in organic reactions, the preparation of benzimidazoles has gained considerable attention in recent years. here, a comparative study on the synthesis of benzimidazoles from aromatic, aliphatic and heterocyclic carboxylic acid, benzonitrile and o-phenylenediamine under...