A previous manuscript on this website, SURGICALLY PRODUCED VOLUME AND PRESSURE OVERLOAD HEART FAILURE MODELS IN SWINE, discussed heart failure models that could be produced in swine using selected surgical techniques. Pressure overload hypertrophy is produced by surgical banding of the great vessels of the heart and leads to concentric hypertrophy of the heart. Volume overload hypertrophy of th...

The study's objectives were to investigate nuclear stereology and to determine the level of p62, a protein involved in nuclear transport, in human cardiomyocytes from patients with heart failure due to ischemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM). We studied 23 human hearts: 10 had ICM, 10 had DCM, and three were from control subjects. The size of the nucleus was significantly ...

Background Patients with end stage dilated cardiomyopathy exhibit extensive remodeling of the left ventricle, annular dilation, and significant mitral and tricuspid regurgitation. These changes increase perioperative morbidity and mortality, and emphasize patient candidacy for heart transplantation. We previously published that Reductive Annuloplasty of Double (mitral and tricuspid) Orifices co...

OBJECTIVES The purpose of this study was to document the various causes of dilated cardiomyopathy in a large group of adult patients with congestive heart failure. BACKGROUND Previous reports of the causes of dilated cardiomyopathy have usually been case reports of a single specific etiology or review articles. The frequency of any single specific heart muscle disease is largely unknown. ME...

AIMS Atrial function is an important component in overall cardiovascular performance. However, information on atrial function in dilated cardiomyopathy is limited. This study aimed to assess atrial function in dilated cardiomyopathy and to investigate if parameters of atrial function are more impaired in Chagas dilated cardiomyopathy (CDC) than in idiopathic dilated cardiomyopathy (IDC). METH...

CONVENTIONAL treatment of patients with dilated cardiomyopathy has focused on the use of diuretic, inotropic, and vasodilator drugs. Despite the development of new vasodilators and inotropic agents, the bleak prognosis for these patients has changed little. An innovative and somewhat radical approach to the therapy of dilated cardiomyopathy was reported in 1975 by Waagstein et al. l in Goteborg...

Patients with dilated cardiomyopathy have multiple factors that predispose to thromboembolic events. However, reports of the incidence of thromboembolic events in this population vary widely. There has never been a controlled study of long-term anticoagulation among patients with congestive heart failure due to dilated cardiomyopathy. In this report we review the available published data regard...

INTRODUCTION AND OBJECTIVES Previous studies on the influence of Chagas disease on mortality in patients with heart failure were limited by the heterogeneity of the patient populations. Few data are available on the association between the underlying cause of dilated cardiomyopathy and long-term prognosis. The aims of this study were to identify risk factors for mortality in patients with dilat...