ecent advancements in the management of patients with cute coronary syndromes and chronic coronary artery isease have contributed to a decreasing number of ischemic atients developing advanced left ventricular dysfunction nd heart failure. Trends in clinical practices using device herapy in patients with heart failure and left ventricular ysfunction indicate that the incidence of nonischemic or...

background chronic heart failure (chf) is associated with unpredictably increased prevalence of hospital admissions. self-care is one of the most important aspects of management for patients with chf. self-care adequacy has led to increased satisfaction, independence in daily activities, reduced stress, and morbidity. objectives we aimed to assess the relationship between self-care behavior and...

n-terminal pro β-type natriuretic peptide (nt-probnp) is a valuable marker for monitoring the response to treatment in patients with heart failure. based on the clinically observed improvement of heart failure symptoms early after cardiac resynchronization therapy (crt), we sought to investigate whether crt induce any significant reduction in the plasma level of nt-probnp in three days after im...

We define cardiomyokines as heart-derived secreted proteins that affect cardiovascular function via autocrine, paracrine and/or endocrine mechanisms. The subject of this review is the cardiomyokine, mesencephalic astrocyte-derived neurotrophic factor (MANF). The expression of MANF is increased in the ischemic heart, in part, through activation of ER stress, a condition that drastically impairs ...

Evidence is accumulating to support the presence of P2X purinergic receptors in the heart. However, the biological role of this receptor remains to be defined. The objectives here were to determine the role of cardiac P2X receptors in modulating the progression of post-myocardial infarction ischemic heart failure and to investigate the underlying mechanism. The P2X4 receptor (P2X4R) is an impor...

INTRODUCTION Tricuspid Annular Plane Systolic Excursion (TAPSE) has independent prognostic value in heart failure patients but may be influenced by left ventricular (LV) ejection fraction. The present study assessed the association of TAPSE and clinical factors, global and regional LV function in 634 patients admitted for symptomatic heart failure. METHODS & RESULTS TAPSE were correlated with...

Since 1996, the National Heart, Lung, and Blood Institute-sponsored Women’s Ischemia Syndrome Evaluation (WISE) has been investigating pathophysiological processes underlying ischemic heart disease in women related outcomes. Recent findings have focused on with signs symptoms of ischemia no obstructive coronary arteries (INOCA) their elevated risk for failure preserved ejection fraction (HFpEF)...

INTRODUCTION AND OBJECTIVES To assess the impact of a program integrating cardiology and primary care in clinical practice, compared with usual care. The integrated care consists of a hospital cardiologist in each primary care clinic, shared clinical history, joint practice guidelines, consultation sessions, and other coordinating tools. METHODS Observational, cross-sectional study of 2 serie...