The ability to reprogram somatic cell nuclei back into a pluripotent epigenetic state provides exciting new possibilities for in vitro research and cell transplantation therapy. There has been a significant quantity of recent research studies demonstrating that this epigenetic reprogramming process is possible with human and non-human primate somatic cells. In this review, various methodologies...

Arrhythmogenic Cardiomyopathy (ACM) is a rare genetic cardiac disease predominantly associated with mutations in genes of the desmosomes and characterized by arrhythmia fibro-fatty replacement myocardium. We generated human induced pluripotent stem cells (hiPSCs) from one patient affected ACM carrying heterozygous c.1643delG (p.G548VfsX15) PKP2 mutation then corrected using CRISPR/Cas9 technolo...

Abstract Wheat ( Triticum aestivum L.) breeding involves improvement of a wide range traits. However, selection for these traits is only acceptable if the end use quality wheat not compromised. In hard red spring wheat, predominant flour bread. this study, milling and baking characteristics were compared in ‘Apogee’ near-isogenic line Apogee (‘A30’) that contains spontaneous segmental deletion ...

Global warming is expected to increase the frequency and intensity of heatwaves, resulting in more common combined acute hyperthermia hypoxia conditions fish farms. Such poor thermal oxygenation induce problems, including growth losses, increased pathogens pressure mortality. Selective breeding a promising solution improve resistance non-optimal water quality. Indeed, genetic variability surviv...