In the course of our previous work we isolated alkaloids such as agroclavine-I and epoxy-agroclavine-I from Penicillium citrinum VKM FW-800 as a microorganism isolated from permafrost1,2). This fungus was shown to coproduce two other alkaloid compounds, which were extractable only under acidic conditions. Positive staining by Dragendorff's reagent but negative Ehrlich reaction suggested the occ...

Objective: Acanthus syriacus (AS) is one of the valuable herbal plants with immunomodulatory potentials. The aim of this study is to assemble a phytochemical investigation of A. syriacus exploring its anti-inflammatory and antinociceptive properties...

In the course of our screening program fbr new antimicrobial substances from microorganisms, a bacterial strain, SC-1801, was found to produce new antibiotics TI801 A, B, C, and D, Here we report the taxonomy of the producing organism, fermentation and isolation, structure elucidation, and biological activity of the antibiotics. They are new quinone and hydroquinone antibiotics and are active a...

A new crystalline antifungal compound, myriocin, has been isolated from culture filtrates and mycelium of the thermophilic ascomycete Myriococcum albomyces. Myriocin is strongly active in vitro against yeasts and dermatophytes. This paper deals with the production, isolation, and purification, as well as the physical, chemical and biological properties of myriocin and one of its derivatives, an...

Two novel metabolites, cymbimicins A and B, were isolated from the culture broth of a strain of Micromonospora sp. by screening for cyclophilin binding metabolites from actinomycete strains. Cymbimicin A binds to cyclophilin A with a high affinity six fold lower than to that of cyclosporin A. The binding affinity of cymbimicin B is about 100 times lower. The taxonomy of the producing strain, fe...

a peer-reviewed, open access online international journal which publishes original research papers. The welcomes submission from scholars and experts for possible publication all over the world. scope of includes: Pharmaceutical research, chemistry biochemistry naturally occurring compounds, biological evaluation crude extracts, ethnomedicine, traditional complementary medicine, ethnopharmacolo...

a peer-reviewed, open access online international journal which publishes original research papers. The welcomes submission from scholars and experts for possible publication all over the world. scope of includes: Pharmaceutical research, chemistry biochemistry naturally occurring compounds, biological evaluation crude extracts, ethnomedicine, traditional complementary medicine, ethnopharmacolo...

a peer-reviewed, open access online international journal which publishes original research papers. The welcomes submission from scholars and experts for possible publication all over the world. scope of includes: Pharmaceutical research, chemistry biochemistry naturally occurring compounds, biological evaluation crude extracts, ethnomedicine, traditional complementary medicine, ethnopharmacolo...

a peer-reviewed, open access online international journal which publishes original research papers. The welcomes submission from scholars and experts for possible publication all over the world. scope of includes: Pharmaceutical research, chemistry biochemistry naturally occurring compounds, biological evaluation crude extracts, ethnomedicine, traditional complementary medicine, ethnopharmacolo...

peptaibols in microbial culture extracts3~5). Here we report the isolation and structure elucidation of peptaibolin (1, Fig. 1) as an unusual representative of the peptaibol family of lipophilic antibiotics. 1 was disclosed in two fungal strains, Sepedonium sp. HKI-0117 and Sepedonium ampullosporum HKI-0053 coproducing the neuroleptic peptaibol-type antibiotic ampullosporin5). In contrast to th...