Acetyl-CoA carboxylase (ACC) is a crucial enzyme in fatty acid metabolism, which plays major role the occurrence and development of certain tumours. Herein, one potential ACC inhibitor (6a) was identified through high-throughput virtual screening (HTVS), series 4-phenoxy-phenyl isoxazoles were synthesised for structure-activity relationship (SAR) studies. Among these compounds, 6g exhibited mos...